Potassium permanganate-acridine yellow chemiluminescence system for the determination of fluvoxamine, isoniazid and ceftriaxone

• Published in: Luminescence (Chichester, England) Vol. 29; no. 8; pp. 1053 - 1058
• Main Authors: Abolhasani, Jafar, Hassanzadeh, Javad
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01-12-2014; Wiley Subscription Services, Inc
• Subjects: acridine yellow; Aminoacridines - chemistry; Calibration; Ceftriaxone - analysis; Ceftriaxone - blood; Ceftriaxone - urine; Chemiluminescence; drug; Drugs; Fluvoxamine - analysis; Fluvoxamine - blood; Fluvoxamine - urine; Human; Humans; Isoniazid - analysis; Isoniazid - blood; Isoniazid - urine; Luminescence; Luminescent Measurements - methods; Optimization; permanganate; Potassium Permanganate - chemistry; Reproducibility of Results; Tablets - analysis; Urine; Wavelengths; acridine yellow; permanganate; chemiluminescence; drug
• ISSN: 1522-7235; 1522-7243
• DOI: 10.1002/bio.2659

ABSTRACT
Based on the oxidation of acridine yellow by permanganate in basic medium, a new chemiluminescence system was developed for the sensitive determination of some important drugs. The remarkable inhibiting effect of fluvoxamine, ceftriaxone and isoniazid on this reaction was applied to their detection. A possible mechanism was proposed for this system based on chemiluminescence emission wavelengths and experimental observations. Under optimum conditions, calibration graphs were obtained for 1 × 10−9 to 1 × 10−6 mol/L of fluvoxamine; 2 × 10−8 to 8 × 10−6 mol/L of ceftriaxone and 5 × 10−8 to 4 × 10−5 mol/L of isoniazid. This proposed method was satisfactorily used in the determination of these drugs in pharmaceutical samples and human urine and serum. Copyright © 2014 John Wiley & Sons, Ltd.