Single nucleotide polymorphisms at erythropoietin, superoxide dismutase 1, splicing factor, arginine/serin-rich 15 and plasmacytoma variant translocation genes association with diabetic nephropathy

• Published in: Saudi journal of kidney diseases and transplantation Vol. 25; no. 3; pp. 577 - 581
• Main Authors: al-Wahib, Maysa, Husayn, Nasir, Abd al-Ghani, Amal, Dashti, Ali Abd al-Samad, al-Yatama, Nur, al-Wahib, Salah
• Format: Journal Article
• Language: English
• Published: Riyadh, Saudi Arabia Saudi Center for Organ Transplantation 01-05-2014; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Case-Control Studies; Development and progression; Diabetic nephropathies; Diabetic Nephropathies - genetics; Diagnosis; Erythropoietin; Erythropoietin - genetics; Gene Frequency; Genetic aspects; Genetic Predisposition to Disease; Humans; Nuclear Proteins - genetics; Phenotype; Polymorphism, Single Nucleotide; Proteins - genetics; Risk Factors; RNA, Long Noncoding; RNA-Binding Proteins - genetics; Serine-Arginine Splicing Factors; Single nucleotide polymorphisms; Superoxide Dismutase - genetics; Superoxide Dismutase-1; Translocation (Genetics); اعتلال الكلى السكري; الأحماض الأمينية; الإريثروبويتين; الاضطرابات الوراثية; التشخيص; النوكليوتيدات; تعدد الأشكال الوراثية; سوبر أكسيد ديسميوتاز; ورم البلازما
• ISSN: 1319-2442; 2320-3838
• DOI: 10.4103/1319-2442.132190

A number of genes have been identified in diabetic nephropathy. Association between diabetes-associated nephropathy and polymorphisms in the erythropoietin (EPO) gene, variants in the superoxide dismutase 1 (SOD1) gene and plasmacytoma variant translocation 1 (PVT1) gene have been identified. The EPO, SOD1:SFRS15 and PVT1 genes were genotyped using the single nucleotide polymorphism (SNP) technique in 38 diabetic nephropathy patients (Group 1) compared with 64 diabetic type 2 subjects without nephropathy (Group 2) at the Mubarak Alkabeer Hospital, Kuwait. The frequency of the risk allele T of the EPO (rs1617640) gene was high in both groups (0.96 in Group 1 and 0.92 in Group 2). Similarly, SNPs of the PVT1 (rs2720709) gene showed a higher frequency of the risk allele G in both groups (0.70 in the Group 1 and 0.68 in Group 2). Although the frequency of the risk allele A was higher than the frequency of the non-risk allele C of the SOD1 : SFRS15 gene in both groups, the lowest probability value was observed in those gene SNPs (P = 0.05). We observed that the A allele of the SOD1 : SFRS15 gene (rs17880135) was more frequently present in Group 1 (0.75) compared with Group 2 (0.62). Susceptibility to diabetes-associated nephropathy is partially mediated by genetic predisposition, and screening tests may open the gate for new therapeutic approaches.