A randomized controlled trial of the effects of hydrochlorothiazide on overactive bladder and idiopathic hypercalciuria

• Published in: Saudi journal of kidney diseases and transplantation Vol. 28; no. 3; pp. 566 - 570
• Main Authors: Azimnejad, Atifah, Naziri, Mahdiah, Rafi, Muhammad, Yousefichaijan, Parsa, Durrah, Fatimah
• Format: Journal Article
• Language: English
• Published: Riyadh, Saudi Arabia Saudi Center for Organ Transplantation 01-05-2017; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Bladder; Care and treatment; Children & youth; Drug dosages; Girls; Health aspects; Hydrochlorothiazide; Hypercalciuria; Parents & parenting; Pediatrics; Substance abuse treatment; Urinary incontinence; Urinary tract diseases; Urinary tract infections; Urine; Urogenital system; Young adults; إدرار البول; الآثار الجانبية; الأدوية; متلازمة فرط نشاط المثانة
• ISSN: 1319-2442; 2320-3838
• DOI: 10.4103/1319-2442.206458

Overactive bladder is a stressful condition which affects around 15%–20% of 5-
year-old and up to 2% of young adults. One of the most common causes of overactive bladder is
hypercalciuria. Our study investigated the effect of hydrochlorothiazide (HCTZ) on overactive
bladder and hypercalciuria. This randomized controlled trial was conducted on 88 patients with
overactive bladder and idiopathic hypercalciuria. They were randomly divided into the
intervention group receiving 1 mg/kg/day of HCTZ for 3 months, and the control group receiving
training without any intervention. Treatment compliance and response were reviewed monthly in
each patient using a 30-day bedwetting diary. In the 1st month, the mean of bedwetting was 14.47
7.06 and 12.61 7.57 in the intervention and control groups, respectively (P = 0.23). In the 2nd
month, it was 10.04 6.32 and 10.79 7.83 in the intervention and control groups, respectively
(P = 0.62); and in the 3rd month, it was 6.49 7.13 and 7.64 7.95 in the intervention and control
groups, respectively (P = 0.59). There was no significant difference between the two groups.
Thus, use of HCTZ was not found to be better than urine retention control training. Therefore,
one may conclude that treating hypercalciuria with HCTZ had no demonstrable effect on
overactive bladder.