A SIMPLE DIASTEREOSELECTIVE SYNTHESIS OF CYCLOHEXYLNORSTATINE AND ALLOCYCLOHEXYLNORSTATINE

Cyclohexylnorstatine [(2R, 3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid] (1) and allocyclohexylnorstatine [(2S, 3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid] (2), designed as key amino acids in renin inhibitors, were synthesized diastereoselectively and simply from Boc-L-phenylalaninol.

Saved in:

Bibliographic Details
Published in:	Chemical & pharmaceutical bulletin Vol. 37; no. 9; pp. 2570 - 2572
Main Authors:	HARADA, Hiromu, TSUBAKI, Atsushi, KAMIJO, Tetsuhide, IIZUKA, Kinji, KISO, Yoshiaki
Format:	Journal Article
Language:	English
Published:	Tokyo The Pharmaceutical Society of Japan 1989 Maruzen
Subjects:	Aliphatic compounds allocyclohexylnorstatine Chemistry cyclohexylnorstatine Exact sciences and technology Organic chemistry Preparations and properties renin inhibitor transition-state analogue α-hydroxy-β-amino acid Aminoalcohol Hydroxyacid Hydrochlorides Aliphatic compound Saturated compound Monocyclic compound Diastereoselectivity
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Cyclohexylnorstatine [(2R, 3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid] (1) and allocyclohexylnorstatine [(2S, 3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid] (2), designed as key amino acids in renin inhibitors, were synthesized diastereoselectively and simply from Boc-L-phenylalaninol.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.37.2570