A clinical trial testing the efficacy of PDT in preventing amputation in diabetic patients
Highlights • We developed a low cost PDT protocol to treat the diabetic feet. • Rate of amputation was 35 times smaller in the PDT group. • Increased efficiency to treat diabetic feet can be of use in public health.
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| Published in: | Photodiagnosis and photodynamic therapy Vol. 11; no. 3; pp. 342 - 350 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
01-09-2014
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| Abstract | Highlights • We developed a low cost PDT protocol to treat the diabetic feet. • Rate of amputation was 35 times smaller in the PDT group. • Increased efficiency to treat diabetic feet can be of use in public health. |
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| AbstractList | •We developed a low cost PDT protocol to treat the diabetic feet.•Rate of amputation was 35 times smaller in the PDT group.•Increased efficiency to treat diabetic feet can be of use in public health.
The feet of diabetic patients continue to be an unsolved problem in medicine. Uncontrolled neuropathy, ulceration and infection usually lead to amputation and presently there is no effective and reliable method that can be used to provide an efficient cure. Overall improvement in the salvage strategies, based on comprehensive pre-clinical evaluation, debridement, antibiotic therapy and follow up, has shown improvements in certain hospital settings, but the general picture for patients with diabetic foot is to have some sort of amputation, especially in underserved populations. It is clearly necessary to develop novel treatment strategies for this worldwide health problem. Photodynamic therapy (PDT) is a treatment modality that uses light to generate in situ reactive oxygen species, which can cause cell death. PDT can be used to treat several diseases, including foot infections that do not respond well to antibiotic therapy. There are several characteristics of PDT that make it potentially ideal to treat diabetic feet: the photosensitizer is non-toxic in the dark, but after illumination it becomes a very efficient antimicrobial agent with topical use, and it can regenerate small bones, such as the phalanges. However, PDT is still not used in clinical practice to treat diabetic feet. Therefore, we decided to perform a clinical study to prove that PDT is an effective method to avoid amputation of infected diabetic feet. An inexpensive PDT protocol was developed and applied to 18 patients with osteomyelitis, classified as Grade 3 on the Wagner scale. Only one of these patients suffered amputation. At least two of them were cured from resistant bacteria strains without intravenous antibiotic therapy. In the control group of 16 patients, all of them ended up suffering amputation. The rate of amputation in the PDT group was 0.029 times the rate in the control group and the difference is clearly statistically significant (p=0.002). The feet of diabetic patients continue to be an unsolved problem in medicine. Uncontrolled neuropathy, ulceration and infection usually lead to amputation and presently there is no effective and reliable method that can be used to provide an efficient cure. Overall improvement in the salvage strategies, based on comprehensive pre-clinical evaluation, debridement, antibiotic therapy and follow up, has shown improvements in certain hospital settings, but the general picture for patients with diabetic foot is to have some sort of amputation, especially in underserved populations. It is clearly necessary to develop novel treatment strategies for this worldwide health problem. Photodynamic therapy (PDT) is a treatment modality that uses light to generate in situ reactive oxygen species, which can cause cell death. PDT can be used to treat several diseases, including foot infections that do not respond well to antibiotic therapy. There are several characteristics of PDT that make it potentially ideal to treat diabetic feet: the photosensitizer is non-toxic in the dark, but after illumination it becomes a very efficient antimicrobial agent with topical use, and it can regenerate small bones, such as the phalanges. However, PDT is still not used in clinical practice to treat diabetic feet. Therefore, we decided to perform a clinical study to prove that PDT is an effective method to avoid amputation of infected diabetic feet. An inexpensive PDT protocol was developed and applied to 18 patients with osteomyelitis, classified as Grade 3 on the Wagner scale. Only one of these patients suffered amputation. At least two of them were cured from resistant bacteria strains without intravenous antibiotic therapy. In the control group of 16 patients, all of them ended up suffering amputation. The rate of amputation in the PDT group was 0.029 times the rate in the control group and the difference is clearly statistically significant (p=0.002). Highlights • We developed a low cost PDT protocol to treat the diabetic feet. • Rate of amputation was 35 times smaller in the PDT group. • Increased efficiency to treat diabetic feet can be of use in public health. |
| Author | Adami, Fernando, PhD Tardivo, João Paulo, PhD Baptista, Mauricio S., PhD Pinhal, Maria Aparecida S., PhD Correa, João Antonio, PhD |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24814697$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1371/journal.pone.0003326 10.1002/lsm.10226 10.1111/php.12264 10.2147/VHRM.S3162 10.1038/nrendo.2009.243 10.1089/pho.2010.2803 10.1089/pho.2008.2252 10.1097/01.sla.0000164172.28918.3f 10.4239/wjd.v2.i2.24 10.1053/j.jfas.2010.12.009 10.1016/S0140-6736(10)61853-3 10.1177/107110078100200202 10.1039/b311900a 10.1002/(SICI)1096-9101(2000)26:3<308::AID-LSM9>3.0.CO;2-B 10.1055/s-0029-1214162 10.1055/s-0029-1214166 10.1016/j.freeradbiomed.2011.05.023 10.1002/lsm.1105 10.1016/S1572-1000(05)00097-9 10.1093/jac/42.1.13 10.1016/j.pdpdt.2009.10.008 10.1097/01.prs.0000227675.63744.af 10.1590/S0100-879X2010007500141 10.1002/dmrr.2247 10.1097/PRS.0b013e3182001f0f 10.1007/s10096-012-1574-1 10.1016/S1572-1000(05)00110-9 10.1007/s12038-008-0040-9 10.1039/B507082A 10.1002/lsm.20962 10.1016/S1067-2516(97)80116-0 10.1016/j.fcl.2004.09.004 10.1016/j.jphotobiol.2003.06.002 |
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| Keywords | Osteomyelitis Antimicrobial PDT Singlet oxygen PACT Diabetic foot Clinical Diabetes Wagner scale |
| Language | English |
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| References | Missoni, Kalenic, Vukelic, De Syo, Belicza, Kern (bib0020) 2006; 60 Ertugrul, Oncul, Tulek, Willke, Sacar, Tunccan (bib0050) 2012; 31 Dai, Huang, Hamblin (bib0120) 2009; 6 Peloi, Soares, Biondo, Souza, Hioka, Kimura (bib0080) 2008; 33 Usacheva, Teichert, Biel (bib0135) 2001; 29 Tardivo, Baptista (bib0130) 2012 Brasileiro, Oliveira, Monteiro, Chen, Pinho, Molkenthin (bib0030) 2005; 4 Baptista, Wainwright (bib0095) 2011; 44 Edmonds (bib0025) 2009; 5 Peters, Lipsky, Berendt, Embil, Lavery, Senneville (bib0045) 2012; 28 Braakenburg, Obdeijn, Feitz, van Rooij, van Griethuysen, Klinkenbijl (bib0185) 2006; 118 Wainwright (bib0100) 2005; 2 Usacheva, Teichert, Biel (bib0140) 2003; 71 Dowd, Wolcott, Sun, McKeehan, Smith, Rhoads (bib0035) 2008; 3 Kowalski, Matsuda, Sorenson, Gundrum, Agger (bib0165) 2011; 50 Alwan, Maclean, Riley, d’Espaignet, Mathers, Stevens (bib0005) 2010; 376 Kashef, Esmaeeli Djavid, Siroosy, Taghi Khani, Hesami Zokai, Fateh (bib0075) 2011; 3 Richard, Sotto, Lavigne (bib0055) 2011; 2 Tardivo, Giglio, Oliveira C.Sd., Gabrielli, Junqueira, Tada (bib0125) 2005; 2 Henke, Blackburn, Wainess, Cowan, Terando, Proctor (bib0175) 2005; 241 Wainwright (bib0070) 1998; 42 Tardivo, Baptista (bib0115) 2009; 27 Gogia, Meehan, Di Cesare, Jamali (bib0040) 2009; 23 Rao, Ziran, Lipsky (bib0170) 2011; 127 Sammarco (bib0010) 2005; 10 Fang, Galiano (bib0015) 2009; 23 Murdoch, Armstrong, Dacus, Laughlin, Morgan, Lavery (bib0060) 1997; 36 Usacheva, Teichert, Biel (bib0145) 2003; 33 Bacellar, Pavani, Sales, Itri, Wainwright, Baptista (bib0150) 2014 Oliveira, Turchiello, Kowaltowski, Indig, Baptista (bib0105) 2011; 51 Wagner (bib0155) 1981; 2 Baran, Giesselman, Hu, Biel, Foster (bib0180) 2010; 42 Bisland, Chien, Wilson, Burch (bib0085) 2006; 5 Hamblin, Hasan (bib0110) 2004; 3 Maier, Anegg, Fell, Rehak, Ratzenhofer, Tomaselli (bib0160) 2000; 26 Game (bib0065) 2010; 6 Goto, Iriuchishima, Horaguchi, Tokuhashi, Nagai, Harada (bib0090) 2011; 29 Fang (10.1016/j.pdpdt.2014.04.007_bib0015) 2009; 23 Maier (10.1016/j.pdpdt.2014.04.007_bib0160) 2000; 26 Tardivo (10.1016/j.pdpdt.2014.04.007_bib0115) 2009; 27 Kowalski (10.1016/j.pdpdt.2014.04.007_bib0165) 2011; 50 Murdoch (10.1016/j.pdpdt.2014.04.007_bib0060) 1997; 36 Kashef (10.1016/j.pdpdt.2014.04.007_bib0075) 2011; 3 Dowd (10.1016/j.pdpdt.2014.04.007_bib0035) 2008; 3 Usacheva (10.1016/j.pdpdt.2014.04.007_bib0145) 2003; 33 Missoni (10.1016/j.pdpdt.2014.04.007_bib0020) 2006; 60 Edmonds (10.1016/j.pdpdt.2014.04.007_bib0025) 2009; 5 Game (10.1016/j.pdpdt.2014.04.007_bib0065) 2010; 6 Baptista (10.1016/j.pdpdt.2014.04.007_bib0095) 2011; 44 Henke (10.1016/j.pdpdt.2014.04.007_bib0175) 2005; 241 Gogia (10.1016/j.pdpdt.2014.04.007_bib0040) 2009; 23 Peters (10.1016/j.pdpdt.2014.04.007_bib0045) 2012; 28 Richard (10.1016/j.pdpdt.2014.04.007_bib0055) 2011; 2 Wagner (10.1016/j.pdpdt.2014.04.007_bib0155) 1981; 2 Rao (10.1016/j.pdpdt.2014.04.007_bib0170) 2011; 127 Peloi (10.1016/j.pdpdt.2014.04.007_bib0080) 2008; 33 Hamblin (10.1016/j.pdpdt.2014.04.007_bib0110) 2004; 3 Oliveira (10.1016/j.pdpdt.2014.04.007_bib0105) 2011; 51 Bisland (10.1016/j.pdpdt.2014.04.007_bib0085) 2006; 5 Brasileiro (10.1016/j.pdpdt.2014.04.007_bib0030) 2005; 4 Wainwright (10.1016/j.pdpdt.2014.04.007_bib0100) 2005; 2 Usacheva (10.1016/j.pdpdt.2014.04.007_bib0140) 2003; 71 Ertugrul (10.1016/j.pdpdt.2014.04.007_bib0050) 2012; 31 Baran (10.1016/j.pdpdt.2014.04.007_bib0180) 2010; 42 Dai (10.1016/j.pdpdt.2014.04.007_bib0120) 2009; 6 Bacellar (10.1016/j.pdpdt.2014.04.007_bib0150) 2014 Usacheva (10.1016/j.pdpdt.2014.04.007_bib0135) 2001; 29 Alwan (10.1016/j.pdpdt.2014.04.007_bib0005) 2010; 376 Tardivo (10.1016/j.pdpdt.2014.04.007_bib0130) 2012 Sammarco (10.1016/j.pdpdt.2014.04.007_bib0010) 2005; 10 Goto (10.1016/j.pdpdt.2014.04.007_bib0090) 2011; 29 Tardivo (10.1016/j.pdpdt.2014.04.007_bib0125) 2005; 2 Wainwright (10.1016/j.pdpdt.2014.04.007_bib0070) 1998; 42 Braakenburg (10.1016/j.pdpdt.2014.04.007_bib0185) 2006; 118 |
| References_xml | – volume: 60 start-page: 43 year: 2006 end-page: 50 ident: bib0020 article-title: [Role of yeasts in diabetic foot ulcer infection] publication-title: Acta Med Croat contributor: fullname: Kern – volume: 10 start-page: 55 year: 2005 end-page: 74 ident: bib0010 article-title: Management of soft tissue deficiency of the hallux: salvage in trauma, diabetes, and following surgical complications publication-title: Foot Ankle Clin contributor: fullname: Sammarco – volume: 29 start-page: 165 year: 2001 end-page: 173 ident: bib0135 article-title: Comparison of the methylene blue and toluidine blue photobactericidal efficacy against gram-positive and gram-negative microorganisms publication-title: Laser Surg Med contributor: fullname: Biel – volume: 33 start-page: 231 year: 2008 end-page: 237 ident: bib0080 article-title: Photodynamic effect of light-emitting diode light on cell growth inhibition induced by methylene blue publication-title: J Biosci contributor: fullname: Kimura – volume: 42 start-page: 13 year: 1998 end-page: 28 ident: bib0070 article-title: Photodynamic antimicrobial chemotherapy (PACT) publication-title: J Antimicrob Chemother contributor: fullname: Wainwright – volume: 376 start-page: 1861 year: 2010 end-page: 1868 ident: bib0005 article-title: Monitoring and surveillance of chronic non-communicable diseases: progress and capacity in high-burden countries publication-title: Lancet contributor: fullname: Stevens – volume: 26 start-page: 308 year: 2000 end-page: 315 ident: bib0160 article-title: Hyperbaric oxygen and photodynamic therapy in the treatment of advanced carcinoma of the cardia and the esophagus publication-title: Laser Surg Med contributor: fullname: Tomaselli – volume: 33 start-page: 311 year: 2003 end-page: 319 ident: bib0145 article-title: The interaction of lipopolysaccharides with phenothiazine dyes publication-title: Laser Surg Med contributor: fullname: Biel – volume: 23 start-page: 141 year: 2009 end-page: 147 ident: bib0015 article-title: Adjunctive therapies in the treatment of osteomyelitis publication-title: Semin Plast Surg contributor: fullname: Galiano – volume: 118 start-page: 390 year: 2006 end-page: 397 ident: bib0185 article-title: The clinical efficacy and cost effectiveness of the vacuum-assisted closure technique in the management of acute and chronic wounds: a randomized controlled trial publication-title: Plast Reconstr Surg contributor: fullname: Klinkenbijl – volume: 6 start-page: 43 year: 2010 end-page: 47 ident: bib0065 article-title: Management of osteomyelitis of the foot in diabetes mellitus publication-title: Nat Rev Endocrinol contributor: fullname: Game – volume: 6 start-page: 170 year: 2009 end-page: 188 ident: bib0120 article-title: Photodynamic therapy for localized infections—state of the art publication-title: Photodiagn Photodyn Ther contributor: fullname: Hamblin – volume: 71 start-page: 87 year: 2003 end-page: 98 ident: bib0140 article-title: The role of the methylene blue and toluidine blue monomers and dimers in the photoinactivation of bacteria publication-title: J Photochem Photobiol B: Biol contributor: fullname: Biel – volume: 127 start-page: 177S year: 2011 end-page: 187S ident: bib0170 article-title: Treating osteomyelitis: antibiotics and surgery publication-title: Plast Reconstr Surg contributor: fullname: Lipsky – volume: 3 start-page: e3326 year: 2008 ident: bib0035 article-title: Polymicrobial nature of chronic diabetic foot ulcer biofilm infections determined using bacterial tag encoded FLX amplicon pyrosequencing (bTEFAP) publication-title: PLoS ONE contributor: fullname: Rhoads – volume: 51 start-page: 824 year: 2011 end-page: 833 ident: bib0105 article-title: Major determinants of photoinduced cell death: subcellular localization versus photosensitization efficiency publication-title: Free Radic Biol Med contributor: fullname: Baptista – volume: 4 start-page: 11 year: 2005 end-page: 21 ident: bib0030 article-title: Diabetic foot: clinical aspects publication-title: J Vasc Bras contributor: fullname: Molkenthin – volume: 3 start-page: 436 year: 2004 end-page: 450 ident: bib0110 article-title: Photodynamic therapy: a new antimicrobial approach to infectious disease? publication-title: Photochem Photobiol Sci: Off J Eur Photochem Assoc Eur Soc Photobiol contributor: fullname: Hasan – volume: 2 start-page: 64 year: 1981 end-page: 122 ident: bib0155 article-title: The dysvascular foot: a system for diagnosis and treatment publication-title: Foot Ankle contributor: fullname: Wagner – volume: 44 start-page: 1 year: 2011 end-page: 10 ident: bib0095 article-title: Photodynamic antimicrobial chemotherapy (PACT) for the treatment of malaria, leishmaniasis and trypanosomiasis publication-title: Braz J Med Biol Res contributor: fullname: Wainwright – volume: 2 start-page: 24 year: 2011 end-page: 32 ident: bib0055 article-title: New insights in diabetic foot infection publication-title: World J Diabetes contributor: fullname: Lavigne – volume: 42 start-page: 728 year: 2010 end-page: 735 ident: bib0180 article-title: Factors influencing tumor response to photodynamic therapy sensitized by intratumor administration of methylene blue publication-title: Laser Surg Med contributor: fullname: Foster – volume: 241 start-page: 885 year: 2005 end-page: 892 ident: bib0175 article-title: Osteomyelitis of the foot and toe in adults is a surgical disease: conservative management worsens lower extremity salvage publication-title: Ann Surg contributor: fullname: Proctor – volume: 3 start-page: 36 year: 2011 end-page: 41 ident: bib0075 article-title: Photodynamic inactivation of drug-resistant bacteria isolated from diabetic foot ulcers publication-title: Iran J Microbiol contributor: fullname: Fateh – volume: 28 start-page: 142 year: 2012 end-page: 162 ident: bib0045 article-title: A systematic review of the effectiveness of interventions in the management of infection in the diabetic foot publication-title: Diabetes Metab Res Rev contributor: fullname: Senneville – volume: 5 start-page: 31 year: 2006 end-page: 38 ident: bib0085 article-title: Pre-clinical in vitro and in vivo studies to examine the potential use of photodynamic therapy in the treatment of osteomyelitis publication-title: Photochem Photobiol Sci: Off J Eur Photochem Assoc Eur Soc Photobiol contributor: fullname: Burch – volume: 31 start-page: 2345 year: 2012 end-page: 2352 ident: bib0050 article-title: A prospective, multi-center study: factors related to the management of diabetic foot infections publication-title: Eur J Clin Microbiol Infect Dis contributor: fullname: Tunccan – volume: 23 start-page: 100 year: 2009 end-page: 107 ident: bib0040 article-title: Local antibiotic therapy in osteomyelitis publication-title: Semin Plast Surg contributor: fullname: Jamali – volume: 36 start-page: 204 year: 1997 end-page: 208 ident: bib0060 article-title: The natural history of great toe amputations publication-title: J Foot Ankle Surg: Off Publ Amer Coll Foot Ankle Surg contributor: fullname: Lavery – volume: 29 start-page: 183 year: 2011 end-page: 189 ident: bib0090 article-title: Therapeutic effect of photodynamic therapy using Na-pheophorbide a on osteomyelitis models in rats publication-title: Photomed Laser Surg contributor: fullname: Harada – volume: 2 start-page: 263 year: 2005 end-page: 272 ident: bib0100 article-title: The development of phenothiazinium photosensitisers publication-title: Photodiagn Photodyn Ther contributor: fullname: Wainwright – volume: 5 start-page: 949 year: 2009 end-page: 963 ident: bib0025 article-title: The treatment of diabetic foot infections: focus on ertapenem publication-title: Vasc Health Risk Manage contributor: fullname: Edmonds – start-page: 121 year: 2012 end-page: 131 ident: bib0130 article-title: Photodynamic therapy in the treatment of osteomyelitis publication-title: Osteomyelitis contributor: fullname: Baptista – year: 2014 ident: bib0150 article-title: Membrane damage efficiency of phenothiazinium photosensitizers publication-title: Photochem Photobiol contributor: fullname: Baptista – volume: 50 start-page: 171 year: 2011 end-page: 175 ident: bib0165 article-title: The effect of residual osteomyelitis at the resection margin in patients with surgically treated diabetic foot infection publication-title: J Foot Ankle Surg: Off Publ Amer Coll Foot Ankle Surg contributor: fullname: Agger – volume: 2 start-page: 175 year: 2005 end-page: 191 ident: bib0125 article-title: Methylene blue in photodynamic therapy: from basic mechanisms to clinical applications publication-title: Photodiagn Photodyn Ther contributor: fullname: Tada – volume: 27 start-page: 145 year: 2009 end-page: 150 ident: bib0115 article-title: Treatment of osteomyelitis in the feet of diabetic patients by photodynamic antimicrobial chemotherapy publication-title: Photomed Laser Surg contributor: fullname: Baptista – volume: 3 start-page: e3326 year: 2008 ident: 10.1016/j.pdpdt.2014.04.007_bib0035 article-title: Polymicrobial nature of chronic diabetic foot ulcer biofilm infections determined using bacterial tag encoded FLX amplicon pyrosequencing (bTEFAP) publication-title: PLoS ONE doi: 10.1371/journal.pone.0003326 contributor: fullname: Dowd – volume: 33 start-page: 311 year: 2003 ident: 10.1016/j.pdpdt.2014.04.007_bib0145 article-title: The interaction of lipopolysaccharides with phenothiazine dyes publication-title: Laser Surg Med doi: 10.1002/lsm.10226 contributor: fullname: Usacheva – volume: 60 start-page: 43 year: 2006 ident: 10.1016/j.pdpdt.2014.04.007_bib0020 article-title: [Role of yeasts in diabetic foot ulcer infection] publication-title: Acta Med Croat contributor: fullname: Missoni – year: 2014 ident: 10.1016/j.pdpdt.2014.04.007_bib0150 article-title: Membrane damage efficiency of phenothiazinium photosensitizers publication-title: Photochem Photobiol doi: 10.1111/php.12264 contributor: fullname: Bacellar – volume: 5 start-page: 949 year: 2009 ident: 10.1016/j.pdpdt.2014.04.007_bib0025 article-title: The treatment of diabetic foot infections: focus on ertapenem publication-title: Vasc Health Risk Manage doi: 10.2147/VHRM.S3162 contributor: fullname: Edmonds – volume: 6 start-page: 43 year: 2010 ident: 10.1016/j.pdpdt.2014.04.007_bib0065 article-title: Management of osteomyelitis of the foot in diabetes mellitus publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2009.243 contributor: fullname: Game – volume: 29 start-page: 183 year: 2011 ident: 10.1016/j.pdpdt.2014.04.007_bib0090 article-title: Therapeutic effect of photodynamic therapy using Na-pheophorbide a on osteomyelitis models in rats publication-title: Photomed Laser Surg doi: 10.1089/pho.2010.2803 contributor: fullname: Goto – volume: 27 start-page: 145 year: 2009 ident: 10.1016/j.pdpdt.2014.04.007_bib0115 article-title: Treatment of osteomyelitis in the feet of diabetic patients by photodynamic antimicrobial chemotherapy publication-title: Photomed Laser Surg doi: 10.1089/pho.2008.2252 contributor: fullname: Tardivo – volume: 241 start-page: 885 year: 2005 ident: 10.1016/j.pdpdt.2014.04.007_bib0175 article-title: Osteomyelitis of the foot and toe in adults is a surgical disease: conservative management worsens lower extremity salvage publication-title: Ann Surg doi: 10.1097/01.sla.0000164172.28918.3f contributor: fullname: Henke – volume: 2 start-page: 24 year: 2011 ident: 10.1016/j.pdpdt.2014.04.007_bib0055 article-title: New insights in diabetic foot infection publication-title: World J Diabetes doi: 10.4239/wjd.v2.i2.24 contributor: fullname: Richard – volume: 3 start-page: 36 year: 2011 ident: 10.1016/j.pdpdt.2014.04.007_bib0075 article-title: Photodynamic inactivation of drug-resistant bacteria isolated from diabetic foot ulcers publication-title: Iran J Microbiol contributor: fullname: Kashef – volume: 50 start-page: 171 year: 2011 ident: 10.1016/j.pdpdt.2014.04.007_bib0165 article-title: The effect of residual osteomyelitis at the resection margin in patients with surgically treated diabetic foot infection publication-title: J Foot Ankle Surg: Off Publ Amer Coll Foot Ankle Surg doi: 10.1053/j.jfas.2010.12.009 contributor: fullname: Kowalski – volume: 376 start-page: 1861 year: 2010 ident: 10.1016/j.pdpdt.2014.04.007_bib0005 article-title: Monitoring and surveillance of chronic non-communicable diseases: progress and capacity in high-burden countries publication-title: Lancet doi: 10.1016/S0140-6736(10)61853-3 contributor: fullname: Alwan – volume: 2 start-page: 64 year: 1981 ident: 10.1016/j.pdpdt.2014.04.007_bib0155 article-title: The dysvascular foot: a system for diagnosis and treatment publication-title: Foot Ankle doi: 10.1177/107110078100200202 contributor: fullname: Wagner – volume: 3 start-page: 436 year: 2004 ident: 10.1016/j.pdpdt.2014.04.007_bib0110 article-title: Photodynamic therapy: a new antimicrobial approach to infectious disease? publication-title: Photochem Photobiol Sci: Off J Eur Photochem Assoc Eur Soc Photobiol doi: 10.1039/b311900a contributor: fullname: Hamblin – volume: 26 start-page: 308 year: 2000 ident: 10.1016/j.pdpdt.2014.04.007_bib0160 article-title: Hyperbaric oxygen and photodynamic therapy in the treatment of advanced carcinoma of the cardia and the esophagus publication-title: Laser Surg Med doi: 10.1002/(SICI)1096-9101(2000)26:3<308::AID-LSM9>3.0.CO;2-B contributor: fullname: Maier – volume: 23 start-page: 100 year: 2009 ident: 10.1016/j.pdpdt.2014.04.007_bib0040 article-title: Local antibiotic therapy in osteomyelitis publication-title: Semin Plast Surg doi: 10.1055/s-0029-1214162 contributor: fullname: Gogia – volume: 23 start-page: 141 year: 2009 ident: 10.1016/j.pdpdt.2014.04.007_bib0015 article-title: Adjunctive therapies in the treatment of osteomyelitis publication-title: Semin Plast Surg doi: 10.1055/s-0029-1214166 contributor: fullname: Fang – volume: 51 start-page: 824 year: 2011 ident: 10.1016/j.pdpdt.2014.04.007_bib0105 article-title: Major determinants of photoinduced cell death: subcellular localization versus photosensitization efficiency publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2011.05.023 contributor: fullname: Oliveira – volume: 29 start-page: 165 year: 2001 ident: 10.1016/j.pdpdt.2014.04.007_bib0135 article-title: Comparison of the methylene blue and toluidine blue photobactericidal efficacy against gram-positive and gram-negative microorganisms publication-title: Laser Surg Med doi: 10.1002/lsm.1105 contributor: fullname: Usacheva – volume: 2 start-page: 175 year: 2005 ident: 10.1016/j.pdpdt.2014.04.007_bib0125 article-title: Methylene blue in photodynamic therapy: from basic mechanisms to clinical applications publication-title: Photodiagn Photodyn Ther doi: 10.1016/S1572-1000(05)00097-9 contributor: fullname: Tardivo – volume: 42 start-page: 13 year: 1998 ident: 10.1016/j.pdpdt.2014.04.007_bib0070 article-title: Photodynamic antimicrobial chemotherapy (PACT) publication-title: J Antimicrob Chemother doi: 10.1093/jac/42.1.13 contributor: fullname: Wainwright – volume: 6 start-page: 170 year: 2009 ident: 10.1016/j.pdpdt.2014.04.007_bib0120 article-title: Photodynamic therapy for localized infections—state of the art publication-title: Photodiagn Photodyn Ther doi: 10.1016/j.pdpdt.2009.10.008 contributor: fullname: Dai – volume: 118 start-page: 390 year: 2006 ident: 10.1016/j.pdpdt.2014.04.007_bib0185 article-title: The clinical efficacy and cost effectiveness of the vacuum-assisted closure technique in the management of acute and chronic wounds: a randomized controlled trial publication-title: Plast Reconstr Surg doi: 10.1097/01.prs.0000227675.63744.af contributor: fullname: Braakenburg – volume: 44 start-page: 1 year: 2011 ident: 10.1016/j.pdpdt.2014.04.007_bib0095 article-title: Photodynamic antimicrobial chemotherapy (PACT) for the treatment of malaria, leishmaniasis and trypanosomiasis publication-title: Braz J Med Biol Res doi: 10.1590/S0100-879X2010007500141 contributor: fullname: Baptista – volume: 28 start-page: 142 issue: Suppl. 1 year: 2012 ident: 10.1016/j.pdpdt.2014.04.007_bib0045 article-title: A systematic review of the effectiveness of interventions in the management of infection in the diabetic foot publication-title: Diabetes Metab Res Rev doi: 10.1002/dmrr.2247 contributor: fullname: Peters – volume: 127 start-page: 177S issue: Suppl. 1 year: 2011 ident: 10.1016/j.pdpdt.2014.04.007_bib0170 article-title: Treating osteomyelitis: antibiotics and surgery publication-title: Plast Reconstr Surg doi: 10.1097/PRS.0b013e3182001f0f contributor: fullname: Rao – volume: 31 start-page: 2345 year: 2012 ident: 10.1016/j.pdpdt.2014.04.007_bib0050 article-title: A prospective, multi-center study: factors related to the management of diabetic foot infections publication-title: Eur J Clin Microbiol Infect Dis doi: 10.1007/s10096-012-1574-1 contributor: fullname: Ertugrul – volume: 2 start-page: 263 year: 2005 ident: 10.1016/j.pdpdt.2014.04.007_bib0100 article-title: The development of phenothiazinium photosensitisers publication-title: Photodiagn Photodyn Ther doi: 10.1016/S1572-1000(05)00110-9 contributor: fullname: Wainwright – volume: 33 start-page: 231 year: 2008 ident: 10.1016/j.pdpdt.2014.04.007_bib0080 article-title: Photodynamic effect of light-emitting diode light on cell growth inhibition induced by methylene blue publication-title: J Biosci doi: 10.1007/s12038-008-0040-9 contributor: fullname: Peloi – volume: 5 start-page: 31 year: 2006 ident: 10.1016/j.pdpdt.2014.04.007_bib0085 article-title: Pre-clinical in vitro and in vivo studies to examine the potential use of photodynamic therapy in the treatment of osteomyelitis publication-title: Photochem Photobiol Sci: Off J Eur Photochem Assoc Eur Soc Photobiol doi: 10.1039/B507082A contributor: fullname: Bisland – volume: 4 start-page: 11 year: 2005 ident: 10.1016/j.pdpdt.2014.04.007_bib0030 article-title: Diabetic foot: clinical aspects publication-title: J Vasc Bras contributor: fullname: Brasileiro – volume: 42 start-page: 728 year: 2010 ident: 10.1016/j.pdpdt.2014.04.007_bib0180 article-title: Factors influencing tumor response to photodynamic therapy sensitized by intratumor administration of methylene blue publication-title: Laser Surg Med doi: 10.1002/lsm.20962 contributor: fullname: Baran – start-page: 121 year: 2012 ident: 10.1016/j.pdpdt.2014.04.007_bib0130 article-title: Photodynamic therapy in the treatment of osteomyelitis contributor: fullname: Tardivo – volume: 36 start-page: 204 year: 1997 ident: 10.1016/j.pdpdt.2014.04.007_bib0060 article-title: The natural history of great toe amputations publication-title: J Foot Ankle Surg: Off Publ Amer Coll Foot Ankle Surg doi: 10.1016/S1067-2516(97)80116-0 contributor: fullname: Murdoch – volume: 10 start-page: 55 year: 2005 ident: 10.1016/j.pdpdt.2014.04.007_bib0010 article-title: Management of soft tissue deficiency of the hallux: salvage in trauma, diabetes, and following surgical complications publication-title: Foot Ankle Clin doi: 10.1016/j.fcl.2004.09.004 contributor: fullname: Sammarco – volume: 71 start-page: 87 year: 2003 ident: 10.1016/j.pdpdt.2014.04.007_bib0140 article-title: The role of the methylene blue and toluidine blue monomers and dimers in the photoinactivation of bacteria publication-title: J Photochem Photobiol B: Biol doi: 10.1016/j.jphotobiol.2003.06.002 contributor: fullname: Usacheva |
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| Snippet | Highlights • We developed a low cost PDT protocol to treat the diabetic feet. • Rate of amputation was 35 times smaller in the PDT group. • Increased... •We developed a low cost PDT protocol to treat the diabetic feet.•Rate of amputation was 35 times smaller in the PDT group.•Increased efficiency to treat... The feet of diabetic patients continue to be an unsolved problem in medicine. Uncontrolled neuropathy, ulceration and infection usually lead to amputation and... |
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| SubjectTerms | Adult Aged Aged, 80 and over Amputation Antimicrobial Clinical Diabetes Diabetic foot Diabetic Foot - therapy Drug Combinations Female Hematology, Oncology and Palliative Medicine Humans Internal Medicine Male Methylene Blue - administration & dosage Middle Aged Organ Sparing Treatments - methods Osteomyelitis Osteomyelitis - therapy PACT PDT Photochemotherapy - methods Radiation-Sensitizing Agents - therapeutic use Singlet oxygen Tolonium Chloride - administration & dosage Treatment Outcome Wagner scale |
| Title | A clinical trial testing the efficacy of PDT in preventing amputation in diabetic patients |
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