Brain structural changes and their correlation with vascular disease in type 2 diabetes mellitus patients： a voxel-based morphometric study

• Published in: Neural regeneration research Vol. 9; no. 16; pp. 1548 - 1556
• Main Authors: Wang, Chunxia, Fu, Kailiang, Liu, Huaijun, Xing, Fei, Zhang, Songyun
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 15-08-2014; Medknow Publications & Media Pvt. Ltd; Department of Medical Imaging, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China%Department of Endocrinology, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China; Medknow Publications & Media Pvt Ltd
• Subjects: 2型糖尿病; Ankle; Automation; Blood circulation disorders; Body mass index; Brain; Cholesterol; Cognition disorders; Cognitive ability; Complications and side effects; Dementia; Diabetes; Diagnosis; Fasting; Glucose; Homeostasis; Hypertension; Lipids; Lipoproteins; Morphometrics (Biology); Pathogenesis; Peptides; Registration; Risk factors; Software; Technical Updates; Triglycerides; Type 2 diabetes; Veins & arteries; 体素; 形态测量; 患者; 糖化血红蛋白; 结构变化; 脑结构; 血管疾病; China; albuminuria; diabetes mellitus; nerve regeneration; neural regeneration; ankle-brachial index
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.139482

Voxel-based morphometry has been used in the study of alterations in brain structure in type 1 diabetes mellitus patients. These changes are associated with clinical indices. The age at onset, pathogenesis, and treatment of type 1 diabetes mellitus are different from those for type 2 diabetes mellitus. Thus, type 1 and type 2 diabetes mellitus may have different impacts on brain structure. Only a few studies of the alterations in brain structure in type 2 diabetes mellitus patients using voxel-based morphometry have been conducted, with inconsistent results. We detected subtle changes in the brain structure of 23 cases of type 2 diabetes mellitus, and demonstrated that there was no significant difference between the total volume of gray and white matter of the brain of type 2 diabetes mellitus patients and that in controls. Regional atrophy of gray matter mainly occurred in the right temporal and left occipital cortex, while regional atrophy of white matter involved the right temporal lobe and the right cerebellar hemisphere. The ankle-brachial index in patients with type 2 diabetes mellitus strongly correlated with the volume of brain regions in the default mode network. The ankle-brachial index, followed by the level of glycosylated hemoglobin, most strongly correlated with the volume of gray matter in the right temporal lobe. These data suggest that voxel-based morphometry could detect small structural changes in patients with type 2 diabetes mellitus. Early macrovascular atherosclerosis may play a crucial role in subtle brain atro- phy in type 2 diabetes mellitus patients, with chronic hyperglycemia playing a lesser role.