A LIPID LIPASE AGGREGATE AS A NEW TYPE OF IMMOBILIZED ENZYME

Lipid-lipase aggregate was prepared by mixing an aqueous solution of lipase with a benzene solution of synthetic phospholipids. The precipitated solid aggregate catalyzed effectively an asymmetric hydrolysis of water-insoluble (±)-α-acyloxy ester 2__∼ in water-saturated isopropy ether producing (2S,...

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Bibliographic Details
Published in:	Chemical & pharmaceutical bulletin Vol. 39; no. 6; pp. 1632 - 1633
Main Authors:	AKITA, Hiroyuki, UMEZAWA, Isao, MATSUKURA, Hiroko, OISHI, Takeshi
Format:	Journal Article
Language:	English
Published:	Tokyo The Pharmaceutical Society of Japan 1991 Maruzen
Subjects:	asymmetric hydrolysis Biological and medical sciences Biotechnology diltiazem hydrochloride Fundamental and applied biological sciences. Psychology Immobilization of enzymes and other molecules Immobilization techniques lipid-aggregated lipase Methods. Procedures. Technologies water-insoluble substrate α-acyloxy ester Enzyme Calcium antagonist Solubility Micelle Phospholipid Triacylglycerol lipase Lipids Hydrolysis Ester Preparation Aggregate Chemical synthesis Immobilized enzyme
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Summary:	Lipid-lipase aggregate was prepared by mixing an aqueous solution of lipase with a benzene solution of synthetic phospholipids. The precipitated solid aggregate catalyzed effectively an asymmetric hydrolysis of water-insoluble (±)-α-acyloxy ester 2__∼ in water-saturated isopropy ether producing (2S, 3S)-2__∼, a key intermediate for the medicinally active diltiazem hydrochloride 1__∼.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.39.1632