Cardiovagal autonomic function in sedentary and trained offspring of hypertensive parents

• Published in: The Journal of physiology Vol. 565; no. 3; pp. 1031 - 1038
• Main Authors: Lénárd, Zsuzsanna, Studinger, Péter, Mersich, Beatrix, Pavlik, Gábor, Kollai, Mark
• Format: Journal Article
• Language: English
• Published: 9600 Garsington Road , Oxford , OX4 2DQ , UK The Physiological Society 15-06-2005; Blackwell Publishing Ltd; Blackwell Science Inc
• Subjects: Adolescent; Adult; Autonomic Nervous System - physiology; Baroreflex; Blood Pressure; Carotid Arteries - physiology; Exercise - physiology; Family Health; Humans; Hypertension - prevention & control; Integrative Physiology; Oxygen Consumption; Parents; Physical Fitness - physiology; Vagus Nerve - physiology
• ISSN: 0022-3751; 1469-7793
• DOI: 10.1113/jphysiol.2005.083386

In young normotensive subjects, parental hypertension is associated with stiffening of the carotid artery and reduction in
cardiovagal outflow and baroreflex gain. In subjects without parental hypertension regular exercise training was found to
attenuate age-related reduction in carotid compliance and baroreflex gain. The aim of the present study was to test the hypothesis
that regular physical activity is associated with better parameters of carotid artery elasticity, increased cardiovagal outflow
and higher baroreflex gain in normotensive offspring of hypertensive parents. We studied 98 healthy, sedentary or endurance
exercise trained subjects (49 men, 18–27 years of age) with or without family history of hypertension (FH + and FH − , respectively) in a cross-sectional design. In the sedentary group spontaneous baroreflex indices (sequence method and spectral
techniques) were lower in FH + subjects than in their FH − peers, while in trained subjects these indices were not different between FH + and FH − . Furthermore, in the FH + group trained subjects had higher baroreflex indices than their sedentary peers, while in the FH − group no significant differences were found. Carotid compliance and distensibility coefficient (echo-tracking ultrasound
and applanation tonometry) were not different in FH − sedentary and trained subjects, but were higher in FH + trained subjects as compared to their sedentary peers. Significant but modest relationships were found between spontaneous
baroreflex indices and carotid artery elastic parameters across all subjects. Our present data indicate that in subjects with
parental hypertension aerobic exercise training is associated with higher levels of cardiovagal outflow and baroreflex gain,
which finding, however, is not explained by greater elasticity of the carotid artery.