Aldosterone-Producing Adrenal Cortical Cancer A Case Report and Analysis of Steroidogenic Enzymes in the Tumor

• Published in: ENDOCRINE JOURNAL Vol. 44; no. 4; pp. 547 - 552
• Main Authors: MORIOKA, MASAAKI, FURUKAWA, YOJI, KOBAYASHI, TATSUYA, TANAKA, HIROYOSHI, OHASHI, YOZO, JIN, TIE-XIONG
• Format: Journal Article
• Language: English
• Published: Japan The Japan Endocrine Society 1997
• Subjects: Adrenal Cortex Neoplasms - enzymology; Adrenal Cortex Neoplasms - metabolism; Adrenocortical cancer; Aldosterone - biosynthesis; Cytochrome P-450 Enzyme System - analysis; Humans; Hydrocortisone - biosynthesis; Hyperaldosteronism; Hypercortisolism; Male; Middle Aged
• ISSN: 0918-8959; 1348-4540
• DOI: 10.1507/endocrj.44.547

A case of hyperaldosteronism caused by adrenal cortical cancer observed in a 32-year-old man was reported. The patient showed marked hypertension and hypokalemia, but neither obesity nor hyperglycemia was observed. Endocrine studies revealed hyperaldosteronism and concurrent excessive secretion of cortisol, but diurnal rhythms of plasma ACTH and cortisol were normal. Imaging studies revealed a large left adrenal mass, and the positive accumulation of radiolabelled material by adrenal scintigraphy was observed both in the tumor and the contralateral adrenal gland. The removed tumor was predominantly composed of dark compact cells with marked nuclear pleomorphism, and mitotic figures and sinusoidal invasion were also observed. The analysis of steroidogenic enzyme activities revealed that the activity of aldosterone-synthesizing enzyme (P-450aldo) which was usually undetectable in normal adrenal tissues and adenomas other than aldosterone-producing adenoma (APA) was detectable as one-third of that of APA. Although activities of other enzymes were reduced, the expression of P-450aldo activity was considered to be the specific character of this cancer.