RNA binding proteins in the regulation of heart development

• Published in: The international journal of biochemistry & cell biology Vol. 45; no. 11; pp. 2467 - 2478
• Main Authors: Blech-Hermoni, Yotam, Ladd, Andrea N.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-11-2013
• Subjects: Animals; Binding; Biology; cardiovascular diseases; Cardiovascular Diseases - embryology; Cardiovascular Diseases - genetics; cell biology; Cell Lineage; Development; Editing; Gene expression; Gene Expression Regulation, Developmental; Heart; Heart - embryology; Humans; Morphogenesis; Position (location); Proteins; Regulation; Ribonucleic acids; RNA; RNA binding protein; RNA processing; RNA-binding proteins; RNA-Binding Proteins - metabolism; tissue repair; tissues; translation (genetics); Heart; CELF; DM; ESRP; RRM; CHAMP; FXR1; Morphogenesis; how; SRSF; 3′ UTR; Development; DGCR8; miRNA; Csm; OFT; RBM; RNA processing; RBFOX; RBP; RISC; hnRNP; RNA binding protein; HERMES; RS domain; EMT; AVC; DGS; STAR; MBNL; Regulation; KH domain; MET; PTB; heterogeneous nuclear ribonucleoprotein; DiGeorge Syndrome; cardiac helicase activated by MEF2 protein; atrioventricular canal; epithelial splicing regulatory protein; DiGeorge Syndrome critical region gene 8; signal transduction and activation of RNA; outflow tract; epithelial-to-mesenchymal transition; muscleblind-like; mesenchymal-to-epithelial transition; RNA recognition motif; serine/arginine-rich splicing factor; held out wings; hnRNP K homology domain; 3′ untranslated region; CUG-BP, Elav-like family; RNA binding Fox-1 homolog; heart and RRM expressed sequence; dystrophia myotonica (myotonic dystrophy); cardiac-specific isoform of Mov10l1; fragile X mental retardation autosomal homolog 1; RNA-induced silencing complex; polypyrimidine tract binding protein; RNA binding motif; arginine/serine-rich domain; microRNA
• ISSN: 1357-2725; 1878-5875
• DOI: 10.1016/j.biocel.2013.08.008

In vivo, RNA molecules are constantly accompanied by RNA binding proteins (RBPs), which are intimately involved in every step of RNA biology, including transcription, editing, splicing, transport and localization, stability, and translation. RBPs therefore have opportunities to shape gene expression at multiple levels. This capacity is particularly important during development, when dynamic chemical and physical changes give rise to complex organs and tissues. This review discusses RBPs in the context of heart development. Since the targets and functions of most RBPs — in the heart and at large — are not fully understood, this review focuses on the expression and roles of RBPs that have been implicated in specific stages of heart development or developmental pathology. RBPs are involved in nearly every stage of cardiogenesis, including the formation, morphogenesis, and maturation of the heart. A fuller understanding of the roles and substrates of these proteins could ultimately provide attractive targets for the design of therapies for congenital heart defects, cardiovascular disease, or cardiac tissue repair.