Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans - joint RENEB and EURADOS inter-laboratory comparisons

• Published in: International journal of radiation biology Vol. 93; no. 1; pp. 99 - 109
• Main Authors: Ainsbury, Elizabeth, Badie, Christophe, Barnard, Stephen, Manning, Grainne, Moquet, Jayne, Abend, Michael, Antunes, Ana Catarina, Barrios, Lleonard, Bassinet, Celine, Beinke, Christina, Bortolin, Emanuela, Bossin, Lily, Bricknell, Clare, Brzoska, Kamil, Buraczewska, Iwona, Castaño, Carlos Huertas, Čemusová, Zina, Christiansson, Maria, Cordero, Santiago Mateos, Cosler, Guillaume, Monaca, Sara Della, Desangles, François, Discher, Michael, Dominguez, Inmaculada, Doucha-Senf, Sven, Eakins, Jon, Fattibene, Paola, Filippi, Silvia, Frenzel, Monika, Georgieva, Dimka, Gregoire, Eric, Guogyte, Kamile, Hadjidekova, Valeria, Hadjiiska, Ljubomira, Hristova, Rositsa, Karakosta, Maria, Kis, Enikő, Kriehuber, Ralf, Lee, Jungil, Lloyd, David, Lumniczky, Katalin, Lyng, Fiona, Macaeva, Ellina, Majewski, Matthaeus, Vanda Martins, S., McKeever, Stephen W.S., Meade, Aidan, Medipally, Dinesh, Meschini, Roberta, M'kacher, Radhia, Gil, Octávia Monteiro, Montero, Alegria, Moreno, Mercedes, Noditi, Mihaela, Oestreicher, Ursula, Oskamp, Dominik, Palitti, Fabrizio, Palma, Valentina, Pantelias, Gabriel, Pateux, Jerome, Patrono, Clarice, Pepe, Gaetano, Port, Matthias, Prieto, María Jesús, Quattrini, Maria Cristina, Quintens, Roel, Ricoul, Michelle, Roy, Laurence, Sabatier, Laure, Sebastià, Natividad, Sholom, Sergey, Sommer, Sylwester, Staynova, Albena, Strunz, Sonja, Terzoudi, Georgia, Testa, Antonella, Trompier, Francois, Valente, Marco, Hoey, Olivier Van, Veronese, Ivan, Wojcik, Andrzej, Woda, Clemens
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01-01-2017; Taylor and Francis
• Subjects: Biodosimetry; Biological Assay - methods; Clinical Laboratory Medicine; Clinical Medicine; Disaster Planning - methods; European Union; Klinisk laboratoriemedicin; Klinisk medicin; Laboratories; Life Sciences; Medical and Health Sciences; Medicin och hälsovetenskap; physical retrospective dosimetry; radiation accidents; Radiation Exposure - analysis; Radiation Monitoring - methods; RENEB; Reproducibility of Results; Retrospective Studies; Safety Management - methods; Sensitivity and Specificity; Space life sciences; Systems Integration; physical retrospective dosimetry; Biodosimetry; radiation accidents; RENEB
• ISSN: 0955-3002; 1362-3095; 1362-3095
• DOI: 10.1080/09553002.2016.1206233

Purpose: RENEB, 'Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,' is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There is a requirement to test and/or validate these candidate techniques and inter-comparison exercises are a well-established method for such validation.
Materials and methods: The authors present details of inter-comparisons of four such new methods: dicentric chromosome analysis including telomere and centromere staining; the gene expression assay carried out in whole blood; Raman spectroscopy on blood lymphocytes, and detection of radiation-induced thermoluminescent signals in glass screens taken from mobile phones.
Results: In general the results show good agreement between the laboratories and methods within the expected levels of uncertainty, and thus demonstrate that there is a lot of potential for each of the candidate techniques.
Conclusions: Further work is required before the new methods can be included within the suite of reliable dosimetry methods for use by RENEB partners and others in routine and emergency response scenarios.