Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses

• Published in: Neuroscience Vol. 230; pp. 139 - 150
• Main Authors: Berg, L.K, Larsson, M, Morland, C, Gundersen, V
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 29-01-2013; Elsevier
• Subjects: Animals; Biological and medical sciences; Central nervous system; Central neurotransmission. Neuromudulation. Pathways and receptors; electron microscopy; Fundamental and applied biological sciences. Psychology; Hippocampus - cytology; Hippocampus - metabolism; immunocytochemistry; Immunohistochemistry; Male; Medicin och hälsovetenskap; Microscopy, Immunoelectron; Mossy Fibers, Hippocampal - metabolism; Mossy Fibers, Hippocampal - ultrastructure; nerve terminal; Neurology; Post-Synaptic Density - metabolism; Post-Synaptic Density - ultrastructure; postsynaptic density; Presynaptic Terminals - metabolism; Presynaptic Terminals - ultrastructure; Protein Subunits - metabolism; rat; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate - metabolism; Receptors, N-Methyl-D-Aspartate - ultrastructure; Vertebrates: nervous system and sense organs; long term potentiation; PBS; postsynaptic density; rat; N-methyl- d-aspartate; LTP; immunocytochemistry; phosphate buffer saline; EDTA; nerve terminal; ethylenediaminetetraacetic acid; HSA; NMDA; electron microscopy; human serum albumin; Rat; Immunocytochemistry; Rodentia; Central nervous system; Glutamate receptor; Subunit; Encephalon; Vertebrata; Synapse; Nerve ending; Mammalia; Animal; Synaptic plasticity; Postsynaptic density; Localization; NMDA receptor; Hippocampus; Presynaptic
• ISSN: 0306-4522; 1873-7544; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.10.061

Graphical abstract Highlights ► NMDA glutamate receptor subunits are located in mossy fibres. ► Most of the NMDA receptor subunits are present in the postsynaptic membrane. ► GluN1, GluN2B, GluN2D and GluN3B have a presynaptic localization.