Chromatin-Specific Remodeling by HMGB1 and Linker Histone H1 Silences Proinflammatory Genes during Endotoxin Tolerance

• Published in: Molecular and Cellular Biology Vol. 29; no. 7; pp. 1959 - 1971
• Main Authors: Gazzar, Mohamed El, Yoza, Barbara K., Chen, Xiaoping, Garcia, Benjamin A., Young, Nicolas L., McCall, Charles E.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01-04-2009; Taylor & Francis; American Society for Microbiology (ASM)
• Subjects: Cell Line; Chromatin Assembly and Disassembly - drug effects; Endotoxins - pharmacology; Gene Silencing - drug effects; Heterochromatin - metabolism; Histones - metabolism; HMGB1 Protein - metabolism; Humans; I-kappa B Proteins - metabolism; Immune Tolerance - drug effects; Inflammation - genetics; Interleukin-1beta - genetics; Leukocytes - drug effects; Leukocytes - metabolism; Methylation - drug effects; NF-KappaB Inhibitor alpha; Promoter Regions, Genetic; Protein Binding - drug effects; Protein Stability - drug effects; Sepsis - metabolism; Sepsis - pathology; Transcription Factor RelB - metabolism; Transcription, Genetic - drug effects; Tumor Necrosis Factor-alpha - genetics
• ISSN: 0270-7306; 1098-5549; 1098-5549
• DOI: 10.1128/MCB.01862-08

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