Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma

The apoptotic cell recognition receptor Axl is highly expressed on human airway/alveolar macrophages, its expression is driven by the lung microenvironment and is significantly reduced in asthma, which may explain defects in apoptotic cell clearance.

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 140; no. 4; pp. 1144 - 1146.e4
Main Authors:	Grabiec, Aleksander M., PhD, Denny, Nicholas, BA, BMBCh, Doherty, John A., BSc, Happonen, Kaisa E., PhD, Hankinson, Jenny, PhD, Connolly, Emma, MSc, Fife, Mark E., BSc, Fujimori, Toshifumi, PhD, Fujino, Naoya, MD, PhD, Goenka, Anu, MD, Holden, Susan, MSc, Tavernier, Gaël, PhD, Shah, Rajesh, FRCS, Cook, Peter C., PhD, MacDonald, Andrew S., PhD, Niven, Robert M., MD, Dahlbäck, Björn, PhD, Fowler, Stephen J., MD, Simpson, Angela, MD, PhD, Hussell, Tracy, PhD
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-10-2017 Elsevier Limited
Subjects:	Adult Allergy and Immunology Asthma Asthma - genetics Asthma - immunology Axl protein Axl Receptor Tyrosine Kinase Basic Medicine Cell and Molecular Biology Cell- och molekylärbiologi Defects Female Gangrene Humans Immunologi inom det medicinska området Immunology in the medical area Infections Inflammation Kinases Lung - immunology Macrophages - immunology Male Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Middle Aged Nucleosomes Phagocytosis Protein-tyrosine kinase receptors Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - immunology Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - immunology Respiratory tract Rodents Sputum - immunology Viral infections alveolar macrophage asthma airway macrophage interferon inflammation efferocytosis
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