Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma

• Published in: Journal of allergy and clinical immunology Vol. 140; no. 4; pp. 1144 - 1146.e4
• Main Authors: Grabiec, Aleksander M., PhD, Denny, Nicholas, BA, BMBCh, Doherty, John A., BSc, Happonen, Kaisa E., PhD, Hankinson, Jenny, PhD, Connolly, Emma, MSc, Fife, Mark E., BSc, Fujimori, Toshifumi, PhD, Fujino, Naoya, MD, PhD, Goenka, Anu, MD, Holden, Susan, MSc, Tavernier, Gaël, PhD, Shah, Rajesh, FRCS, Cook, Peter C., PhD, MacDonald, Andrew S., PhD, Niven, Robert M., MD, Dahlbäck, Björn, PhD, Fowler, Stephen J., MD, Simpson, Angela, MD, PhD, Hussell, Tracy, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-10-2017; Elsevier Limited
• Subjects: Adult; Allergy and Immunology; Asthma; Asthma - genetics; Asthma - immunology; Axl protein; Axl Receptor Tyrosine Kinase; Basic Medicine; Cell and Molecular Biology; Cell- och molekylärbiologi; Defects; Female; Gangrene; Humans; Immunologi inom det medicinska området; Immunology in the medical area; Infections; Inflammation; Kinases; Lung - immunology; Macrophages - immunology; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Middle Aged; Nucleosomes; Phagocytosis; Protein-tyrosine kinase receptors; Proteins; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - immunology; Receptor Protein-Tyrosine Kinases - genetics; Receptor Protein-Tyrosine Kinases - immunology; Respiratory tract; Rodents; Sputum - immunology; Viral infections; alveolar macrophage; asthma; airway macrophage; interferon; inflammation; efferocytosis
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2017.03.024

The apoptotic cell recognition receptor Axl is highly expressed on human airway/alveolar macrophages, its expression is driven by the lung microenvironment and is significantly reduced in asthma, which may explain defects in apoptotic cell clearance.