Tiragolumab (Anti-TIGIT) in SCLC: Skyscraper-02, a Towering Inferno

• Published in: Lung cancer (Auckland) Vol. 14; pp. 1 - 9
• Main Authors: Brazel, Danielle, Ou, Sai-Hong Ignatius, Nagasaka, Misako
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01-01-2023; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Anemia; Antigens; Cancer; Cancer therapies; Chemotherapy; Clinical trials; Development and progression; FDA approval; Immune system; Immunotherapy; Kinases; Ligands; Lung cancer; Lung cancer, Non-small cell; Medical prognosis; Medical research; Medicine, Experimental; Metastasis; Monoclonal antibodies; Non-small cell lung carcinoma; Pharmacokinetics; Prognosis; Review; Skyscrapers; small cell lung cancer; Small cell lung carcinoma; Statistical significance; T cell receptors; Tall buildings; tigit; tiragolumab; Tumor necrosis factor-TNF; Tumors; tiragolumab; small cell lung cancer; TIGIT; immunotherapy
• ISSN: 1179-2728; 1179-2728
• DOI: 10.2147/LCTT.S379389

Small cell lung cancer (SCLC) is characterized by rapid progression and poor prognosis. Although the phase II CITYSCAPE-02 trial found objective response rate (ORR) and progression-free survival (PFS) of non-small cell lung cancer (NSCLC) patients improved when tiragolumab was added to atezolizumab and chemotherapy, the phase III SKYSCRAPER-02 failed to find PFS or OS benefit in patients with SCLC. Atezolizumab was the first immunotherapy to show survival benefit in extensive SCLC based on the phase III IMpower133 study. Given that immunotherapy has become the standard of care for SCLC patients, further research is needed into ways to augment the immune system to better treat these patients.