Free and Cued Selective Reminding Test sensitivity

• Published in: Alzheimer's & dementia : diagnosis, assessment & disease monitoring Vol. 10; no. 1; p. 75
• Main Authors: Castilhos, Raphael M., Chaves, Marcia L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 2018; John Wiley & Sons, Inc; Elsevier; Wiley
• Subjects: Alzheimer's disease; Bias; Biomarkers; Dementia; Diagnostic tests; Letters to the Editor
• ISSN: 2352-8729; 2352-8729
• DOI: 10.1016/j.dadm.2017.11.005

FCSRT has been suggested by the International Working Group as a test to characterize amnestic syndrome of hippocampal type [2] and in fact has been demonstrating high correlation with AD pathology [3] and high sensitivity to predict mild cognitive impairment conversion to dementia [4]. In other words, the diagnostic test being evaluated should not be a part of the information used to establish the diagnosis [5]. Because there is no gold standard test for the presence of hippocampal amnestic deficits, it would be more useful to compare FCSRT with a larger battery of tests that could more accurately determine the presence of hippocampal amnestic deficits earlier in the disease course. [...]although FCSRT may be useful in determining amnestic syndromes, it is not possible to conclude from this study that the sensitivity of the scale is 100%, because some patients with amnestic presentation of AD may go undetected by this test.