Bcl-2 and the Regulation of Programmed Cell Death

Programmed cell death (PCD) is used to describe a mechanism of cellular demise that is believed to play an important role in a wide variety of physiological situations. The bcl-2 gene has recently emerged as a critical regulator of PCD in a variety of physiological and pathological contexts.

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Bibliographic Details
Published in:	The Journal of cell biology Vol. 124; no. 1/2; pp. 1 - 6
Main Author:	Reed, John C.
Format:	Journal Article
Language:	English
Published:	New York, NY Rockefeller University Press 01-01-1994 The Rockefeller University Press
Subjects:	Ageing, cell death Apoptosis B lymphocytes Biological and medical sciences Cell Compartmentation Cell death Cell growth Cell lines Cell physiology Cells Cellular biology Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 18 Fundamental and applied biological sciences. Psychology Gene expression regulation Genes Humans Mini-Review on Cellular Mechanisms of Disease Series Mini-Reviews Molecular and cellular biology Myeloid cells Neurons Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-bcl-2 T lymphocytes Translocation, Genetic Proteins Cell proliferation Regulation(control) Cell death Review Localization Survival
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Description
Summary:	Programmed cell death (PCD) is used to describe a mechanism of cellular demise that is believed to play an important role in a wide variety of physiological situations. The bcl-2 gene has recently emerged as a critical regulator of PCD in a variety of physiological and pathological contexts.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0021-9525 1540-8140
DOI:	10.1083/jcb.124.1.1