Electrostatic interactions in phospholipid membranes revealed by coherent 2D IR spectroscopy

The inter- and intramolecular interactions of the carbonyl moieties at the polar interface of a phospholipid membrane are probed by using nonlinear femtosecond infrared spectroscopy. Two-dimensional IR correlation spectra separate homogeneous and inhomogeneous broadenings and show a distinct cross-p...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 104; no. 39; pp. 15323 - 15327
Main Authors:	Volkov, V.V, Chelli, R, Zhuang, W, Nuti, F, Takaoka, Y, Papini, A.M, Mukamel, S, Righini, R
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 25-09-2007 National Acad Sciences
Subjects:	Absorption spectra Anisotropy Biological Sciences Biophysics Carbon - chemistry Cell membranes Chemical elements Computer Simulation Correlation analysis Electrostatics Excitons Infrared radiation Infrared spectroscopy Insulin resistance Kinetics Line spectra Lipid Bilayers - chemistry Lipids Membranes Models, Statistical Molecular Conformation Molecules Phospholipids Phospholipids - chemistry Phosphorus Physical Sciences Pumps Spectrophotometry - methods Spectrophotometry, Infrared - methods Spectroscopy, Fourier Transform Infrared Spectrum analysis Static Electricity
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Summary:	The inter- and intramolecular interactions of the carbonyl moieties at the polar interface of a phospholipid membrane are probed by using nonlinear femtosecond infrared spectroscopy. Two-dimensional IR correlation spectra separate homogeneous and inhomogeneous broadenings and show a distinct cross-peak pattern controlled by electrostatic interactions. The inter- and intramolecular electrostatic interactions determine the inhomogeneous character of the optical response. Using molecular dynamics simulation and the nonlinear exciton equations approach, we extract from the spectra short-range structural correlations between carbonyls at the interface.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author contributions: V.V.V. and R.R. designed research; V.V.V., R.C., S.M., and R.R. performed research; F.N. and A.M.P. contributed new reagents/analytic tools; V.V.V., R.C., W.Z., and Y.T. analyzed data; and V.V.V., R.C., W.Z., S.M., and R.R. wrote the paper. Communicated by Peter M. Rentzepis, University of California, Irvine, CA, July 11, 2007
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.0706426104