Membrane-Active Peptides and Their Potential Biomedical Application

• Published in: Pharmaceutics Vol. 15; no. 8; p. 2091
• Main Authors: Gostaviceanu, Andreea, Gavrilaş, Simona, Copolovici, Lucian, Copolovici, Dana Maria
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01-08-2023; MDPI
• Subjects: Amino acids; Antibiotics; Antimicrobial agents; antimicrobial peptides; Bacteria; cancer; cell-penetrating peptides; Drug delivery systems; Drugs; Gases industry; Gram-negative bacteria; Gram-positive bacteria; Health aspects; Insects; Lipids; membrane-active peptides; Membranes; Microorganisms; peptide synthesis; Peptides; Proteins; Review; Salinity; tumor-homing peptides; Vehicles; United States
• ISSN: 1999-4923; 1999-4923
• DOI: 10.3390/pharmaceutics15082091

Membrane-active peptides (MAPs) possess unique properties that make them valuable tools for studying membrane structure and function and promising candidates for therapeutic applications. This review paper provides an overview of the fundamental aspects of MAPs, focusing on their membrane interaction mechanisms and potential applications. MAPs exhibit various structural features, including amphipathic structures and specific amino acid residues, enabling selective interaction with multiple membranes. Their mechanisms of action involve disrupting lipid bilayers through different pathways, depending on peptide properties and membrane composition. The therapeutic potential of MAPs is significant. They have demonstrated antimicrobial activity against bacteria and fungi, making them promising alternatives to conventional antibiotics. MAPs can selectively target cancer cells and induce apoptosis, opening new avenues in cancer therapeutics. Additionally, MAPs serve as drug delivery vectors, facilitating the transport of therapeutic cargoes across cell membranes. They represent a fascinating class of biomolecules with significant potential in basic research and clinical applications. Understanding their mechanisms of action and designing peptides with enhanced selectivity and efficacy will further expand their utility in diverse fields. Exploring MAPs holds promise for developing novel therapeutic strategies against infections, cancer, and drug delivery challenges.