Proteostasis impairment in protein-misfolding and -aggregation diseases

Highlights • Cells possess a complex proteostasis network (PN) to ensure protein homeostasis. • Aggregates permanently engage molecular chaperones and other PN components. • The PN is challenged by chronic stress in protein-aggregation diseases and aging. • Overtaxing the PN drives a vicious cycle o...

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Bibliographic Details
Published in:	Trends in cell biology Vol. 24; no. 9; pp. 506 - 514
Main Authors:	Hipp, Mark S, Park, Sae-Hun, Hartl, F. Ulrich
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-09-2014
Subjects:	Aging - genetics Aging - pathology degradation Homeostasis Humans molecular chaperones Molecular Chaperones - genetics neurodegenerative disease Pathology protein (mis)folding protein aggregation Protein Aggregation, Pathological - genetics Protein Folding Proteins - genetics Proteins - metabolism Proteolysis proteostasis Proteostasis Deficiencies - genetics Proteostasis Deficiencies - pathology protein (mis)folding degradation neurodegenerative disease molecular chaperones proteostasis protein aggregation
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Summary:	Highlights • Cells possess a complex proteostasis network (PN) to ensure protein homeostasis. • Aggregates permanently engage molecular chaperones and other PN components. • The PN is challenged by chronic stress in protein-aggregation diseases and aging. • Overtaxing the PN drives a vicious cycle of disease progression with eventual proteostasis collapse.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0962-8924 1879-3088
DOI:	10.1016/j.tcb.2014.05.003