Systemic Inflammation after Aneurysmal Subarachnoid Hemorrhage

• Published in: International journal of molecular sciences Vol. 24; no. 13; p. 10943
• Main Authors: Chai, Chang-Zhang, Ho, Ue-Cheung, Kuo, Lu-Ting
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30-06-2023; MDPI
• Subjects: Aneurysm; Antigens; Biomarkers; Catecholamines; cerebral aneurysm; Chemokines; Clinical trials; Complications; Consciousness; Cytokines; Dexmedetomidine; Diseases; Edema; Flow velocity; Health aspects; Hemodynamics; Hemoglobin; Hemorrhage; Hemorrhagic Stroke; Humans; Immune system; Inflammation; Inflammation - complications; Intracranial Aneurysm - complications; Ischemia; Magnetic resonance imaging; Metabolites; Mortality; Nervous system; Neurological diseases; Neutrophils; Nosocomial infections; Review; Stroke; Stroke (Disease); Subarachnoid hemorrhage; Subarachnoid Hemorrhage - etiology; systemic inflammation; Transcription factors; Trauma; Traumatic brain injury; Tumor necrosis factor-TNF; systemic inflammation; cerebral aneurysm; subarachnoid hemorrhage
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms241310943

Aneurysmal subarachnoid hemorrhage (aSAH) is one of the most severe neurological disorders, with a high mortality rate and severe disabling functional sequelae. Systemic inflammation following hemorrhagic stroke may play an important role in mediating intracranial and extracranial tissue damage. Previous studies showed that various systemic inflammatory biomarkers might be useful in predicting clinical outcomes. Anti-inflammatory treatment might be a promising therapeutic approach for improving the prognosis of patients with aSAH. This review summarizes the complicated interactions between the nervous system and the immune system.