Impact of SumiLarv ® 2MR on Aedes aegypti larvae: a multicenter study in Brazil

• Published in: Parasites & vectors Vol. 17; no. 1; p. 88
• Main Authors: Müller, Josiane Nogueira, Galardo, Allan Kardec Ribeiro, Corrêa, Ana Paula Sales de Andrade, Macoris, Maria de Lourdes da Graça, de Melo-Santos, Maria Alice Varjal, Nakazawa, Mitsue Maia, Martins, Ademir Jesus, Lima, José Bento Pereira
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26-02-2024; BioMed Central; BMC
• Subjects: Aedes - physiology; Aedes aegypti; Animals; Aquatic insects; Bioassays; Brazil - epidemiology; Breeding sites; Chikungunya virus; Containers; Dengue fever; Disease transmission; Emergence; Human diseases; Insecticides; Insecticides - pharmacology; Insects; Instars; Larva; Larvae; Methods; Mortality; Mosquito; Mosquito Control; Mosquito Vectors; Mosquitoes; Proliferation; Public health; Pyriproxyfen; Spinosad; Testing; Vector control; Vector-borne diseases; Zika Virus; Zika Virus Infection - prevention & control; Brazil; Rio de Janeiro Brazil; Pyriproxyfen; Mosquito; Vector control
• ISSN: 1756-3305; 1756-3305
• DOI: 10.1186/s13071-023-06064-w

Aedes aegypti is associated with dengue, Zika, and chikungunya transmission. These arboviruses are responsible for national outbreaks with severe public health implications. Vector control is one of the tools used to prevent mosquito proliferation, and SumiLarv
2MR is an alternative commercial product based on pyriproxyfen for larval/pupal control. In this study, the residual effectiveness of SumiLarv
2MR in different regions of Brazil was evaluated in simulated field conditions.
We conducted a multicenter study across four Brazilian states-Amapá, Pernambuco, Rio de Janeiro, and São Paulo-given the importance to the country's climatic variances in the north, northeast, and southeast regions and their influence on product efficiency. The populations of Ae. aegypti from each location were held in an insectary. Third-instar larvae (L3) were added every 2 weeks to water containers with SumiLarv
2MR discs in 250-, 500- and 1000-l containers in Amapá and Rio de Janeiro, and 100-l containers in Pernambuco and São Paulo, using concentrations of 0.04, 0.08, and 0.16 mg/l.
Adult emergence inhibition over 420 days was observed in all tests conducted at a concentration of 0.16 mg/l; inhibition for 308-420 days was observed for 0.08 mg/l, and 224-420 days for 0.04 mg/l.
Sumilarv
2MR residual activity demonstrated in this study suggests that this new pyriproxyfen formulation is a promising alternative for Aedes control, regardless of climatic variations and ideal concentration, since the SumiLarv
2MR showed adult emergence inhibition of over 80% and residual activity greater than 6 months, a period longer than that recommended by the Ministry of Health of Brazil between product re-application in larval breeding sites.