Usage of Glucagon-Like Peptide-1 for Obesity in Children; Updated Review of Clinicaltrials.gov

• Published in: Journal of multidisciplinary healthcare Vol. 16; pp. 2179 - 2187
• Main Authors: Alorfi, Nasser M, Alshehri, Fahad S
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01-01-2023; Dove; Dove Medical Press
• Subjects: Analysis; Body weight; Children; clinical trials; Diabetes therapy; Diabetics; Drug approval; Exenatide; glp-1; Glucagon; Health aspects; Insulin resistance; Liraglutide; Obesity; Obesity in children; Pediatrics; Review; semaglutide; Surgery; Type 2 diabetes; liraglutide; clinical trials; GLP-1; obesity; exenatide; semaglutide
• ISSN: 1178-2390; 1178-2390
• DOI: 10.2147/JMDH.S419245

Obesity in both adults and children is a primary health concern that can lead to many complications at a young age, including insulin resistance, type 2 diabetes, and other diseases. Glucagon-like peptide-1 receptor agonists (GLP-1) are drugs utilized to treat diabetes, but they are also approved as an adjunct to a low-calorie diet to reduce body weight and to enhance the metabolic profile readings for diabetic and non-diabetic patients. However, their efficacy and safety in children have not been extensively examined.
To identify glucagon-like peptide-1 medications for obesity in pediatric participants (aged up to 17 years old).
Analysis of all clinical trials registered on ClinicalTrials.gov for obesity using GLP-1 as a treatment for children.
As of January 26th, 2023, 10,828 clinical trials were found. The search included childhood obesity using GLP-1. The number of trials on the use of GLP-1 to treat childhood obesity is limited. The final number of analyzed trials was 19. GLP-1 has been shown to result in the effective management of body gain among children.
Exenatide, semaglutide, and liraglutide were the only GLP-1 medications used as the pharmacotherapy option. It has been studied in many circumstances eg, to treat children with severe obesity, PCOS, hypothalamic obesity, glucose tolerance, and as a complementary treatment alongside behavior-lifestyle change and surgery for obesity.