Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics

Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics

Gut microbiota are intricately involved in the development of obesity-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and insulin resistance. In the current review, we discuss the role of gut microbiota in the development of NAFLD by focusing on the mech...

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Bibliographic Details
Published in:International journal of molecular sciences Vol. 17; no. 3; p. 300
Main Authors: He, Xuyun, Ji, Guang, Jia, Wei, Li, Houkai
Format: Journal Article
Language:English
Published: Switzerland MDPI 15-03-2016
MDPI AG
Subjects:
bile acids
choline
Energy Metabolism
Gastrointestinal Microbiome
gut microbiota
Humans
Insulin Resistance
Metabolomics
NAFLD
Non-alcoholic Fatty Liver Disease - microbiology
obesity
Review
choline
NAFLD
bile acids
insulin resistance
gut microbiota
obesity
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Summary:Gut microbiota are intricately involved in the development of obesity-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and insulin resistance. In the current review, we discuss the role of gut microbiota in the development of NAFLD by focusing on the mechanisms of gut microbiota-mediated host energy metabolism, insulin resistance, regulation of bile acids and choline metabolism, as well as gut microbiota-targeted therapy. We also discuss the application of a metabolomic approach to characterize gut microbial metabotypes in NAFLD.
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ISSN:1422-0067
1422-0067
DOI:10.3390/ijms17030300