Microvascular Leakage as Therapeutic Target for Ischemia and Reperfusion Injury

• Published in: Cells (Basel, Switzerland) Vol. 12; no. 10; p. 1345
• Main Authors: Kloka, Jan Andreas, Friedrichson, Benjamin, Wülfroth, Petra, Henning, Rainer, Zacharowski, Kai
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09-05-2023; MDPI
• Subjects: Animal models; Animals; Aorta; Apoptosis; Blood circulation disorders; capillary leak; Care and treatment; Cerebral blood flow; clinical outcome; Clinical outcomes; Complications and side effects; Development and progression; Edema; Fatalities; Heart attacks; Ischemia; Leukocytes; Metabolism; Microvasculature; Models, Animal; Myocardium; organ protection; Oxidative stress; Permeability; Prospective Studies; Reperfusion; Reperfusion injury; Reperfusion Injury - drug therapy; Review; Risk factors; Stroke; Therapeutic targets; Germany; capillary leak; reperfusion injury; edema; organ protection; clinical outcome
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells12101345

Reperfusion injury is a very common complication of various indicated therapies such as the re-opening of vessels in the myocardium or brain as well as reflow in hemodynamic shutdown (cardiac arrest, severe trauma, aortic cross-clamping). The treatment and prevention of reperfusion injury has therefore been a topic of immense interest in terms of mechanistic understanding, the exploration of interventions in animal models and in the clinical setting in major prospective studies. While a wealth of encouraging results has been obtained in the lab, the translation into clinical success has met with mixed outcomes at best. Considering the still very high medical need, progress continues to be urgently needed. Multi-target approaches rationally linking interference with pathophysiological pathways as well as a renewed focus on aspects of microvascular dysfunction, especially on the role of microvascular leakage, are likely to provide new insights.