Effect of polymer-free TiO2 stent coated with abciximab or alpha lipoic acid in porcine coronary restenosis model

• Published in: Journal of cardiology Vol. 64; no. 5; pp. 409 - 418
• Main Authors: Lim, Kyung Seob, DVM, MS, Jeong, Myung Ho, MD, PhD, FACC, FAHA, FESC, Bae, In Ho, PhD, Park, Jun-Kyu, MS, Park, Dae Sung, MS, Kim, Jong Min, MS, Kim, Jung Ha, BS, Kim, Hyung-Seok, MD, PhD, Kim, Yong Sook, PhD, Jeong, Hye-Yun, BS, Song, Sun-Jung, PhD, Yang, Eun Ju, MS, Cho, Dong Lyun, PhD, Sim, Doo Sun, MD, PhD, Park, Keun-Ho, MD, PhD, Hong, Young Joon, MD, PhD, Ahn, Youngkeun, MD, PhD
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-11-2014
• Subjects: Animals; Antibodies, Monoclonal - administration & dosage; Cardiovascular; Coronary Restenosis - pathology; Coronary Restenosis - surgery; Disease Models, Animal; Drug-Eluting Stents; Fibrin; Hyperplasia - prevention & control; Immunoglobulin Fab Fragments - administration & dosage; Inflammation; Male; Neointima - prevention & control; Percutaneous coronary intervention; Percutaneous Coronary Intervention - methods; Polymers; Restenosis; Stents; Swine; Thioctic Acid - administration & dosage; Time Factors; Titanium; Treatment Outcome; Restenosis; Percutaneous coronary intervention; Inflammation; Stents
• ISSN: 0914-5087; 1876-4738
• DOI: 10.1016/j.jjcc.2014.02.015

Abstract Background Polymer-free drug-eluting stents (DES) may overcome the shortcomings of polymer-based DES. The aim of this study was to examine the effect of the polymer-free TiO2 film-coated stent with abciximab or alpha lipoic acid in a porcine coronary overstretch restenosis model. Methods Pigs were randomized into four groups in which the coronary arteries (24 pigs, 48 coronaries in each group) had TiO2 film-coated stent with abciximab (TCA, n = 12), TiO2 film-coated stent with alpha lipoic acid (TCALA, n = 12), biolimus A9-eluting stents with biodegradable polymer (BES, n = 12), and TiO2 film-coated stent (TCstent, n = 12). Histopathologic analysis was performed at 28 days after stenting. Results There was no significant difference in the injury score and internal elastic lamina (IEL) among the four groups. There were significant differences in the lumen area, neointima area, percent area stenosis, fibrin score, and inflammation score among the four groups [2.7 ± 1.0 mm2 , 2.6 ± 0.94 mm2 , 48.9 ± 16.25%, 1.0 (range 0.0–3.0), 1.0 (range 0.0–2.0) in TCA stent group vs. 2.7 ± 1.24 mm2 , 2.9 ± 0.83 mm2 , 53.5 ± 17.19%, 1.0 (range 0.0–2.0), 1.0 (range 0.0–2.0) in TCALA stent group vs. 2.7 ± 1.30 mm2 , 2.6 ± 1.06 mm2 , 50.1 ± 23.20%, 2.0 (range 1.0–3.0), 2.0 (range 1.0–3.0) in BES group vs. 1.7 ± 0.63 mm2 , 3.3 ± 0.58 mm2 , 60.2 ± 10.12%, 0.5 (range 0.0–2.0), 1.0 (range 0.0–2.0) in TC stent group, respectively]. Conclusion TCA and TCALA are more effective to reduce neointimal hyperplasia compared to TC. Moreover, fibrin and inflammation scores are significantly lower in TCA and TCALA than BES in porcine coronary restenosis model.