Stimuli-Responsive Polysaccharide Hydrogels and Their Composites for Wound Healing Applications

• Published in: Polymers Vol. 15; no. 4; p. 986
• Main Authors: Psarrou, Maria, Mitraki, Anna, Vamvakaki, Maria, Kokotidou, Chrysoula
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-02-2023; MDPI
• Subjects: Angiogenesis; Bacteria; Bacterial infections; Biocompatibility; Biodegradability; Biomedical materials; Biopolymers; Blood; Collagen; Colloids in medicine; Composite materials; composites; Design and construction; Enzymes; Extracellular matrix; Growth factors; Health aspects; Hyaluronic acid; Hydrogels; Infections; Inflammation; Materials research; Mechanical properties; Polymeric composites; Polysaccharides; Review; Skin; Stimuli; stimuli-responsive; Ulcers; Wound healing; Greece; composites; polysaccharides; wound healing; hydrogels; biopolymers; stimuli-responsive
• ISSN: 2073-4360; 2073-4360
• DOI: 10.3390/polym15040986

There is a growing concern about wound care, since traditional dressings such as bandages and sutures can no longer meet existing needs. To address the demanding requirements, naturally occurring polymers have been extensively exploited for use in modern wound management. Polysaccharides, being the most abundant biopolymers, have some distinct characteristics, including biocompatibility and biodegradability, which render them ideal candidates for wound healing applications. Combining them with inorganic and organic moieties can produce effective multifunctional composites with the desired mechanical properties, high wound healing efficiencies and excellent antibacterial behavior. Recent research endeavors focus on the development of stimuli-responsive polysaccharide composites for biomedical applications. Polysaccharide composites, being sensitive to the local environment, such as changes of the solution temperature, pH, etc., can sense and react to the wound conditions, thus promoting an effective interaction with the wound. This review highlights the recent advances in stimuli-responsive polysaccharide hydrogels and their composites for use in wound healing applications. The synthetic approaches, physical, chemical, and biochemical properties as well as their function in wound healing will be discussed.