Spot-scanned pancreatic stereotactic body proton therapy: A dosimetric feasibility and robustness study

Highlights • We compared pancreatic cancer SBRT with protons (SBPT) and photons (SB-IMRT). • SBPT planning is associated with significant gastrointestinal sparing. • A 5 mm OTV and SFO-6 mm spot size was the best compromise for target and OAR dose. • Our study offers a critical basis for clinical tr...

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Bibliographic Details
Published in:	Physica medica Vol. 32; no. 2; pp. 331 - 342
Main Authors:	Sio, Terence T, Merrell, Kenneth W, Beltran, Chris J, Ashman, Jonathan B, Hoeft, Kathleen A, Miller, Robert C, Whitaker, Thomas J, Wurgler, Stephanie K, Tryggestad, Erik J
Format:	Journal Article
Language:	English
Published:	Italy Elsevier Ltd 01-02-2016
Subjects:	Feasibility Studies Humans Intensity-modulated radiation therapy Liver Neoplasms - radiotherapy Pancreatic cancer Pancreatic Neoplasms - radiotherapy Proton plan robustness Proton Therapy - methods Radiology Radiometry Radiosurgery - methods Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted Spot-scanned proton therapy Stereotactic body proton therapy Stereotactic body radiation therapy Intensity-modulated radiation therapy Stereotactic body radiation therapy Spot-scanned proton therapy Stereotactic body proton therapy Pancreatic cancer Proton plan robustness
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Summary:	Highlights • We compared pancreatic cancer SBRT with protons (SBPT) and photons (SB-IMRT). • SBPT planning is associated with significant gastrointestinal sparing. • A 5 mm OTV and SFO-6 mm spot size was the best compromise for target and OAR dose. • Our study offers a critical basis for clinical translation SBPT for pancreatic cancer.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1120-1797 1724-191X
DOI:	10.1016/j.ejmp.2015.12.009