3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study

• Published in: Journal of magnetic resonance imaging Vol. 44; no. 5; pp. 1186 - 1196
• Main Authors: Gandy, Stephen J., Lambert, Matthew, Belch, Jill, Cavin, Ian, Crowe, Elena, Littleford, Roberta, MacFarlane, Jennifer A., Matthew, Shona Z., Martin, Patricia, Nicholas, R. Stephen, Struthers, Allan, Sullivan, Frank, Waugh, Shelley A., White, Richard D., Weir-McCall, Jonathan R., Houston, J. Graeme
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01-11-2016; Wiley Subscription Services, Inc; John Wiley and Sons Inc
• Subjects: 3.0T; Adult; Age; Age Distribution; Aged; Aged, 80 and over; Aging - pathology; Aging - physiology; cardiac; Female; Females; Heart; Heart diseases; Heart Ventricles - anatomy & histology; Heart Ventricles - diagnostic imaging; Humans; Image processing; Image segmentation; left ventricle; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - statistics & numerical data; Male; Males; Mass Screening; Middle Aged; MRI; NMR; Nuclear magnetic resonance; Original Research; Population; Population studies; Precession; Reference Values; Scanners; Sex Distribution; Sex Factors; Stroke; Stroke volume; Stroke Volume - physiology; Structure-function relationships; United Kingdom - epidemiology; Ventricle; Ventricular Function, Left - physiology; 3.0T; MRI; left ventricle; cardiac; population
• ISSN: 1053-1807; 1522-2586; 1522-2586
• DOI: 10.1002/jmri.25267

Purpose
To scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T.
Materials and Methods
A population of 1528 volunteers was scanned. A standardized approach was taken to acquire steady‐state free precession (SSFP) LV data in the short‐axis plane, and images were quantified using commercial software. Six observers undertook the segmentation analysis.
Results
Mean values (±standard deviation, SD) were: ejection fraction (EF) = 69 ± 6%, end diastolic volume index (EDVI) = 71 ± 13 ml/m2, end systolic volume index (ESVI) = 22 ± 7 ml/m2, stroke volume index (SVI) = 49 ± 8 ml/m2, and LV mass index (LVMI) = 55 ± 12 g/m2. The mean EF was slightly larger for females (69%) than for males (68%), but all other variables were smaller for females (EDVI 68v77 ml/m2, ESVI 21v25 ml/m2, SVI 46v52 ml/m2, LVMI 49v64 g/m2, all P < 0.05). The mean LV volume data mostly decreased with each age decade (EDVI males: –2.9 ± 1.3 ml/m2, females: –3.1 ± 0.8 ml/m2; ESVI males: –1.3 ± 0.7 ml/m2, females: –1.7 ± 0.5 ml/m2; SVI males: –1.7 ± 0.9 ml/m2, females: –1.4 ± 0.6 ml/m2; LVMI males: –1.6 ± 1.1 g/m2, females: –0.2 ± 0.6 g/m2) but the mean EF was virtually stable in males (0.6 ± 0.6%) and rose slightly in females (1.2 ± 0.5%) with age.
Conclusion
LV reference ranges are provided in this population‐based MR study at 3.0T. The variables are similar to those described at 1.5T, including variations with age and gender. These data may help to support future population‐based MR research studies that involve the use of 3.0T MRI scanners. J. Magn. Reson. Imaging 2016;44:1186–1196.