Cellular Prion Protein Role in Cancer Biology: Is It A Potential Therapeutic Target?

• Published in: Biomedicines Vol. 10; no. 11; p. 2833
• Main Authors: Yousaf, Saba, Ahmad, Muhammad, Wu, Siwen, Zia, Muhammad Anjum, Ahmed, Ishtiaq, Iqbal, Hafiz M. N, Liu, Qingyou, Rehman, Saif ur
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01-11-2022; MDPI
• Subjects: Amino acids; Cancer; cancer biology; Cell growth; Cyclin-dependent kinases; Disease; EP/MAPK pathway; Epigenetics; ERK2 (MAPK1) pathway; Extracellular signal-regulated kinase; Gastric cancer; Gene regulation; Genomes; Health aspects; Heredity; Kinases; Lymphoid cells; Malignancy; Mammalian cells; Mammary gland; MAP kinase; Mesenchyme; Metastases; Mutation; Nervous system; Neural coding; Neurological diseases; p53 Protein; Phase transitions; Polypeptides; prion; Prion protein; Prions; PRNP; Propagation; Prostate; Protein kinase; Proteins; Review; Signal transduction; Therapeutic applications; Therapeutic targets; Tumor suppressor genes; Tumorigenesis; Tumorigenicity; Tumors; Yeast; United States
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines10112833

Cancers are worldwide health concerns, whether they are sporadic or hereditary. The fundamental mechanism that causes somatic or oncogenic mutations and ultimately aids cancer development is still unknown. However, mammalian cells with protein-only somatic inheritance may also contribute to cancerous malignancies. Emerging data from a recent study show that prion-like proteins and prions (PrPC) are crucial entities that have a functional role in developing neurological disorders and cancer. Furthermore, excessive PrPC expression profiling has also been detected in non-neuronal tissues, such as the lymphoid cells, kidney, GIT, lung, muscle, and mammary glands. PrPC expression is strongly linked with the proliferation and metastasis of pancreatic, prostate, colorectal, and breast malignancies. Similarly, experimental investigation presented that the PrPC expression, including the prion protein-coding gene (PRNP) and p53 ag are directly associated with tumorigenicity and metastasis (tumor suppressor gene). The ERK2 (extracellular signal-regulated kinase) pathway also confers a robust metastatic capability for PrPC-induced epithelial to mesenchymal transition. Additionally, prions could alter the epigenetic regulation of genes and overactive the mitogen-activated protein kinase (MAPK) signaling pathway, which promotes the development of cancer in humans. Protein overexpression or suppression caused by a prion and prion-like proteins has also been linked to oncogenesis and metastasis. Meanwhile, additional studies have discovered resistance to therapeutic targets, highlighting the significance of protein expression levels as potential diagnostic indicators and therapeutic targets.