Optical Detection of Cancer Cells Using Lab-on-a-Chip

The global need for accurate and efficient cancer cell detection in biomedicine and clinical diagnosis has driven extensive research and technological development in the field. Precision, high-throughput, non-invasive separation, detection, and classification of individual cells are critical require...

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Bibliographic Details
Published in:	Biosensors (Basel) Vol. 13; no. 4; p. 439
Main Authors:	García-Hernández, Luis Abraham, Martínez-Martínez, Eduardo, Pazos-Solís, Denni, Aguado-Preciado, Javier, Dutt, Ateet, Chávez-Ramírez, Abraham Ulises, Korgel, Brian, Sharma, Ashutosh, Oza, Goldie
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 30-03-2023 MDPI
Subjects:	Analysis Antigens Automation Biomarkers Biosensing Techniques - methods Biosensors Cancer Cancer cells Cancer therapies Cells chemiluminescence Diagnosis Experimental methods Flow cytometry fluorescence Immobilization Lab-on-a-chip Lab-On-A-Chip Devices Medical diagnosis Medical personnel Medical research Metabolism Metastasis Microfluidics Neoplasms - diagnosis optical detection Optical Phenomena Optics Optics and Photonics Practice Proteins Quantum dots Review Spectrum Analysis, Raman surface plasmon resonance SPR Mexico fluorescence optical detection chemiluminescence lab-on-a-chip surface-enhanced Raman scattering SERS cancer surface plasmon resonance SPR
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Summary:	The global need for accurate and efficient cancer cell detection in biomedicine and clinical diagnosis has driven extensive research and technological development in the field. Precision, high-throughput, non-invasive separation, detection, and classification of individual cells are critical requirements for successful technology. Lab-on-a-chip devices offer enormous potential for solving biological and medical problems and have become a priority research area for microanalysis and manipulating cells. This paper reviews recent developments in the detection of cancer cells using the microfluidics-based lab-on-a-chip method, focusing on describing and explaining techniques that use optical phenomena and a plethora of probes for sensing, amplification, and immobilization. The paper describes how optics are applied in each experimental method, highlighting their advantages and disadvantages. The discussion includes a summary of current challenges and prospects for cancer diagnosis.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	2079-6374 2079-6374
DOI:	10.3390/bios13040439