The Role of Adipokines in the Pathogenesis of Psoriasis

• Published in: International journal of molecular sciences Vol. 24; no. 7; p. 6390
• Main Authors: Kiełbowski, Kajetan, Bakinowska, Estera, Ostrowski, Piotr, Pala, Bartłomiej, Gromowska, Ewa, Gurazda, Klaudia, Dec, Paweł, Modrzejewski, Andrzej, Pawlik, Andrzej
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28-03-2023; MDPI
• Subjects: Adipocytes; adipokines; Adipokines - metabolism; Adiponectin; Adiponectin - therapeutic use; Adipose tissue; Adipose Tissue - metabolism; Adipose tissues; Autoimmune diseases; Biopsy; Cytokines; Dendritic cells; Dermatitis; Development and progression; Diagnosis; Disease; Health aspects; Health risk assessment; Humans; Immunomodulation; Infections; Inflammation; Interleukin 17; Interleukin 23; Interleukins; Keratinocytes; Leptin; Leptin - therapeutic use; Lymphocytes; Lymphocytes T; Metabolism; Mutation; Obesity; Pathogenesis; Pathophysiology; Patients; Proteins; Psoriasis; Psoriasis - drug therapy; Psoriasis - etiology; Psoriatic arthritis; Resistin; Review; Risk factors; Skin; T cells; Tumor necrosis factor-TNF; adiponectin; adipokines; cytokines; inflammation; leptin; psoriasis
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms24076390

Psoriasis is a chronic and immune-mediated skin condition characterized by pro-inflammatory cytokines and keratinocyte hyperproliferation. Dendritic cells, T lymphocytes, and keratinocytes represent the main cell subtypes involved in the pathogenesis of psoriasis, while the interleukin-23 (IL-23)/IL-17 pathway enhances the disease progression. Human adipose tissue is an endocrine organ, which secretes multiple proteins, known as adipokines, such as adiponectin, leptin, visfatin, or resistin. Current evidence highlights the immunomodulatory roles of adipokines, which may contribute to the progression or suppression of psoriasis. A better understanding of the complexity of psoriasis pathophysiology linked with adipokines could result in developing novel diagnostic or therapeutic strategies. This review aims to present the pathogenesis of psoriasis and the roles of adipokines in this process.