Proanthocyanidin Structure-Activity Relationship Analysis by Path Analysis Model

• Published in: International journal of molecular sciences Vol. 24; no. 7; p. 6379
• Main Authors: Li, Zhaoxuan, Liu, Jingling, You, Jie, Li, Xin, Liang, Zongsuo, Du, Junli
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28-03-2023; MDPI
• Subjects: Analysis; Antioxidants; Antioxidants - pharmacology; Aqueous solutions; Biological activity; Cancer; Chemical compounds; Diabetes; Diabetes mellitus; Medical research; path analysis; Plant Extracts - pharmacology; Proanthocyanidins; Proanthocyanidins - pharmacology; Rhodiola; Rhodiola crenulata; Seeds; Statistical analysis; structure-activity relation; China; path analysis; proanthocyanidins; structure-activity relation; Rhodiola crenulata
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms24076379

To fully explore the influence mechanism of interactions between different monomer units of proanthocyanidins (PAs) on biological activity, a path analysis model of the PA structure-activity relationship was proposed. This model subdivides the total correlation between each monomer unit and activity into direct and indirect effects by taking into account not only each monomer unit but also the correlation with its related monomer units. In addition, this method can determine the action mode of each monomer unit affecting the activity by comparing the direct and total indirect effects. Finally, the advantage of this model is demonstrated through an influence mechanism analysis of
PA monomer units on antioxidant and anti-diabetes activities.