Angiogenic activity in the sera of patients with post-kidney transplant erythrocytosis

• Published in: Saudi journal of kidney diseases and transplantation Vol. 25; no. 5; pp. 1026 - 1029
• Main Authors: Skhiri, Habib, Hachicha, Jamil, Yaich, Sumayyah, Maktuf, Shukri, Bounemra, Azzah, Alawi, Sabra, Sharaf al-Din, Khalid
• Format: Journal Article
• Language: English
• Published: Riyadh, Saudi Arabia Saudi Center for Organ Transplantation 01-09-2014; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer; Wolters Kluwer Medknow Publications
• Subjects: Biomarkers - blood; Case-Control Studies; Complications; Enzyme-Linked Immunosorbent Assay; Health aspects; Human health and pathology; Humans; Kidney Transplantation - adverse effects; Kidneys; Life Sciences; Neovascularization; Physiological aspects; Polycythemia; Polycythemia - blood; Polycythemia - diagnosis; Polycythemia - etiology; Polycythemia Vera - blood; Polycythemia Vera - etiology; Prospective Studies; Transplantation; Up-Regulation; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - blood; الأمراض; الأوعية الدموية; الكلى; المرضى; المضاعفات; النمو; زرع الأعضاء; كريات الدم الحمراء; Saudi Arabia
• ISSN: 1319-2442; 2320-3838
• DOI: 10.4103/1319-2442.139905

Post-kidney transplant erythrocytosis (PTE) is one of the hematological complications in the renal transplant patients. While its pathogenesis still remains to be elucidated completely, a number of therapies are available for the management of PTE. The aim of this prospective study was to investigate whether angiogenesis may be involved in the pathogenesis of post-transplant erythrocytosis by comparing its level with those of different classes of erythrocytosis [polycythemia vera (PV), idiopathic erythrocytosis and secondary erythrocytosis]. The angiogenic activity was evaluated by the assessment of the serum vascular endothelial growth factor (VEGF) levels, as one of circulating angiogenic factor, using a standardized enzyme-linked immunosorbent assay commercial kit in 13 PTE (2 F / 11 M), in 75 untreated erythrocytosis non-transplant patients and in 21 healthy subjects controls. The results indicated that VEGF was overproduced in advanced and untreated PV patients and to a lesser degree in idiopathic erythrocytosis thus confirming an increased angiogenic activity. However, there is no evidence of increased angiogenesis in PTE and in secondary erythrocytosis. The absence of angiogenesis in PTE and its presence in PV is another argument that the pathogenesis of these two entities is different.