Current Practice in Pediatric Cow's Milk Protein Allergy-Immunological Features and Beyond

• Published in: International journal of molecular sciences Vol. 24; no. 5; p. 5025
• Main Authors: Emmert, Vanessza, Lendvai-Emmert, Dominika, Eklics, Kata, Prémusz, Viktória, Tóth, Gergely Péter
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-03-2023; MDPI
• Subjects: Age; Allergens; Anaphylaxis; Animals; Antigens; Cattle; Cow's milk; cow’s milk protein allergy; epitope; Female; Food allergies; Food allergy; Health aspects; Hypothermia; IgE-mediated; Immunoglobulin E; Immunological tolerance; Immunology; immunotherapy; Milk; Milk Hypersensitivity - therapy; Milk Proteins; non-IgE-mediated; Pathophysiology; Pediatrics; Proteins; Pruritus; Quality of Life; Review; Skin; Vomiting; Hungary; cow’s milk protein allergy; IgE-mediated; epitope; food allergy; non-IgE-mediated; immunotherapy
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms24055025

Cow's milk protein allergy is one of the most common pediatric food allergies. It poses a significant socioeconomic burden in industrialized countries and has a profound effect on the quality of life of affected individuals and their families. Diverse immunologic pathways can lead to the clinical symptoms of cow's milk protein allergy; some of the pathomechanisms are known in detail, but others need further elucidation. A comprehensive understanding of the development of food allergies and the features of oral tolerance could have the potential to unlock more precise diagnostic tools and novel therapeutic approaches for patients with cow's milk protein allergy.