Steroid cell tumor of the ovary presenting with ascites: A rare neoplasm in a postmenopausal woman

• Published in: Journal of mid-life health Vol. 12; no. 1; pp. 82 - 84
• Main Authors: Velamala, Pavani, Gupta, Parikshaa, Sikka, Pooja, Kumar, Divyesh, Rajwanshi, Arvind
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01-01-2021; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Case Report; histopathology; immunohistochemistry; ovarian tumor; sex-cord stromal tumors; steroid cell tumor; virilization; sex-cord stromal tumors; Histopathology; immunohistochemistry; steroid cell tumor; virilization; ovarian tumor
• ISSN: 0976-7800; 0976-7819
• DOI: 10.4103/jmh.JMH_114_20

Steroid cell tumors of the ovary are rare sex-cord stromal tumors, accounting for approximately 0.1% of all ovarian neoplasms. Majority of these tumors are benign, occur in pre-menopausal women and are associated with hyperandrogenism. However, around one-third of cases are malignant and do not present with hormonal manifestations. A 48-year-old post-menopausal woman presented with complaints of gradually increasing progressive abdominal distension over the past 3 months. She had a history of weight gain but denied any symptoms of virilization. On examination, abdominal distension associated with ascites was noted. Serum CA125 level was raised. Contrast-enhanced computed tomography revealed a solid right adnexal mass. Based on the clinical impression of epithelial ovarian malignancy, the patient underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy and infracolic omentectomy. Histopathological examination revealed steroid cell tumor of the not otherwise specified type in the right ovary with the capsular breach. However, all other organs, including the omentum were free of tumor. The index case is unique for its presentation in a post-menopausal woman, association with ascites, elevated CA125 levels and lack of any virilization manifestations. Establishing an early and accurate tissue diagnosis is essential so that appropriate surgical management can be done to prevent the development of metastases in potentially malignant cases.