Effect of lead acetate toxicity on experimental male albino rat

• Published in: Asian Pacific journal of tropical biomedicine Vol. 2; no. 1; pp. 41 - 46
• Main Authors: Ibrahim, Nabil M, Eweis, Esam A, El-Beltagi, Hossam S, Abdel-Mobdy, Yasmin E
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 2012; Asian Pacific Tropical Medicine Press
• Subjects: acetate; ALT; Animals; AST; Blood Cells; Blood Chemical Analysis; Cholinesterase; Hemoglobin; Intoxication; Kidney Function Tests; Lead; Lead acetate; Lead Poisoning - pathology; Lead Poisoning - physiopathology; Liver Function Tests; Male; Organometallic Compounds - toxicity; Original; Rats, Sprague-Dawley; Thyroid Function Tests; Toxicity; T4; AST; Lead acetate; Toxicity; Lead; Hemoglobin; ALT; Intoxication; Cholinesterase; T3
• ISSN: 2221-1691; 2588-9222
• DOI: 10.1016/s2221-1691(11)60187-1

Objective:To evaluate the effect of different doses of lead acetate(1/20,1/40 and 1/60 of LD50)on body weight gain,blood picture,plasma prolein profile and the function of liver,kidney and thyroid gland.Methods:Male albino rats were divided into four groups,the first group represented the health control animals,while the second,third and fourth groups were ingested orally with sub lethal doses of load acetate（1/20,1/40 and 1/60）of the oral LD50,respectively.One dose was ingested every two days during the experimental period（14 weeks）including the adaptation time.Blood was collected and used for all analysis.Results:The results showed that,the ingestion of Pb2+induced significant stimulation in glutamic-pyruvic transaminase（ALT）and glutamic-oxalacetic transaminease（AST）activity.Also,total soluble protein and albumin contents of plasma were significantly decreased,while the content of globulin was changed by the Pb2+treatments.The cholinesteiase activity was inhibited,but the activities of alkaline and acid phosphates and lactate dehydrogenase were stimulated,while plasma glucose level was elevated as a result of lead acetate intoxication.In case of blood picture,Pb2+ingestion reduced the contents of hemoglobin and RBCs count of intoxicated rat’s blood and the plasma levels of T3,T4 and blood WBCs count were decreased.Conclusions:It can be concluded that lead acetate has harmful effect on experimental male albino rats.Therefore,the present work advises people to prevent exposure to the lead compound to avoid injurious hazard risk.