NK-cell activation is associated with increased HIV transcriptional activity following allogeneic hematopoietic cell transplantation

•Graft-versus-host effects may lead to HIV-1 reactivation and cell death of infected pre-HCT CD4+ T cells.•Natural killer cell activation correlates with in vitro HIV-1 transcriptional activity in the setting of HCT.

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Bibliographic Details
Published in:	Blood advances Vol. 2; no. 12; pp. 1412 - 1416
Main Authors:	Hogan, Louise E., Körner, Christian, Hobbs, Kristen, Simoneau, Camille R., Thanh, Cassandra, Gibson, Erica A., Palmer, Christine D., Pandit, Alisha, Marty, Francisco M., Kuritzkes, Daniel R., Jost, Stephanie, Ritz, Jerome, Henrich, Timothy J.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 26-06-2018 American Society of Hematology Elsevier
Subjects:	CD4-Positive T-Lymphocytes - pathology CD4-Positive T-Lymphocytes - virology Cell Death Graft vs Host Disease - virology Hematopoietic Stem Cell Transplantation - methods HIV Infections - therapy HIV-1 - genetics Humans Killer Cells, Natural - immunology Killer Cells, Natural - virology Lymphocyte Activation Stimulus Report Transcription, Genetic Transplantation, Homologous Virus Activation
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Description
Summary:	•Graft-versus-host effects may lead to HIV-1 reactivation and cell death of infected pre-HCT CD4+ T cells.•Natural killer cell activation correlates with in vitro HIV-1 transcriptional activity in the setting of HCT.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2473-9529 2473-9537
DOI:	10.1182/bloodadvances.2018016329