The role of the pathology department in the preanalytical phase of molecular analyses

• Published in: Cancer management and research Vol. 10; pp. 745 - 753
• Main Authors: Susman, Sergiu, Berindan-Neagoe, Ioana, Petrushev, Bobe, Pirlog, Radu, Florian, Ioan-Stefan, Mihu, Carmen-Mihaela, Berce, Cristian, Craciun, Lucian, Grewal, Ravnit, Tomuleasa, Ciprian
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01-01-2018; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Antigens; Automation; Biomarkers; Breast cancer; Deoxyribonucleic acid; DNA; Feasibility studies; fixation; freezing; Genomics; Hematology; Laboratories; Management; Medicine; Methodology; Molecular biology; molecular techniques; Nucleic acids; Pathology; Patient care; Pharmacy; Physicians; Proteins; Proteomics; Quality control; Tumors; fixation; nucleic acids; freezing; molecular techniques; proteins
• ISSN: 1179-1322; 1179-1322
• DOI: 10.2147/CMAR.S150851

After introducing the new molecules for the treatment of patients with tumoral pathology, the therapeutical decision will be taken depending on the molecular profile performed upon the harvested tissues. This major modification makes the molecular and morphological analysis an essential part in the clinical management of patients and the pathologist plays an important role in this process. The quality and reproducibility of the results are imperative today and they depend on both the reliability of the molecular techniques and the quality of the tissue we use in the process. Also, the genomics and proteomics techniques, used increasingly often, require high-quality tissues, and pathology laboratories play a very significant role in the management of all phases of this process. In this paper the parameters which must be followed in order to obtain optimal results within the techniques which analyze nucleic acids and proteins were reviewed.