Toll-like receptor-based adjuvants: enhancing the immune response to vaccines against infectious diseases of chicken

• Published in: Expert review of vaccines Vol. 13; no. 7; p. 909
• Main Authors: Gupta, Shishir Kumar, Deb, Rajib, Dey, Sohini, Chellappa, Madhan Mohan
• Format: Journal Article
• Language: English
• Published: England 01-07-2014
• Subjects: Adjuvants, Immunologic - therapeutic use; Animals; Antibody Formation; Birnaviridae Infections - immunology; Birnaviridae Infections - prevention & control; Chickens; Coronavirus Infections - immunology; Coronavirus Infections - prevention & control; Influenza in Birds - immunology; Influenza in Birds - prevention & control; Marek Disease - immunology; Marek Disease - prevention & control; Myeloid Differentiation Factor 88 - immunology; Newcastle Disease - immunology; Newcastle Disease - prevention & control; Oligodeoxyribonucleotides - immunology; Poultry Diseases - immunology; Poultry Diseases - prevention & control; Salmonella Infections - immunology; Salmonella Infections - prevention & control; Signal Transduction - immunology; Toll-Like Receptors - immunology; Vaccination; cytokine; chicken; poultry; vaccine; infectious disease; agonist; TLR; adjuvants
• ISSN: 1744-8395
• DOI: 10.1586/14760584.2014.920236

Huge productivity loss due to infectious diseases in chickens is a major problem and, hence, robust development of the poultry industry requires control of poultry health. Immunization using vaccines is routine practice; however, to combat infectious diseases, conventional vaccines as well as new-generation recombinant vaccines alone, due to relatively weak immunogenicity, may not be effective enough to provide optimum immunity. With this in mind, there is a need to incorporate better and more suitable adjuvants in the vaccines to elicit the elevated immune response in the host. Over last few decades, with the increase in the knowledge of innate immune functioning, efforts have been made to enhance vaccine potency using novel adjuvants like Toll-like receptor based adjuvant systems. In this review, we will discuss the potential use of toll-like receptor ligands as an adjuvant in vaccines against the infectious diseases of chickens.