LnNP@ZIF8 Smart System for In Situ NIR-II Ratiometric Imaging-Based Tumor Drug Resistance Evaluation

• Published in: Nanomaterials (Basel, Switzerland) Vol. 12; no. 24; p. 4478
• Main Authors: Wang, Qingyuan, Zhang, Zhizheng, Qiu, Dehui, Mao, Xuanxiang, Zhou, Zhaoxi, Xia, Tiansong, Wei, Jifu, Ding, Qiang, Zhang, Xiaobo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-12-2022; MDPI
• Subjects: Antioxidants; Breast cancer; Cancer; Cancer therapies; Chemotherapy; Chloride; Drug delivery; Drug delivery systems; Drug resistance; Drugs; Fluorescence; Health aspects; lanthanide doped nanoparticle; Medical imaging; Metal-organic frameworks; Nanoparticles; NIR-II ratiometric imaging; Oxidative stress; Reactive oxygen species; smart drug delivery system; tumor drug resistance evaluation; Tumors; Vehicles; ZIF8; China; Beijing China; United States > US; Japan; ZIF8; smart drug delivery system; NIR-II ratiometric imaging; lanthanide doped nanoparticle; tumor drug resistance evaluation
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano12244478

Just-in-time evaluation of drug resistance in situ will greatly facilitate the achievement of precision cancer therapy. The rapid elevation of reactive oxygen species (ROS) is the key to chemotherapy. Hence, suppressed ROS production is an important marker for chemotherapy drug resistance. Herein, a NIR-II emission smart nanoprobe (LnNP@ZIF8, consisting of a lanthanide-doped nanoparticle (LnNP) core and metal-organic framework shell (ZIF8)) is constructed for drug delivery and in vivo NIR-II ratiometric imaging of ROS for tumor drug resistance evaluation. The drug-loaded nanoprobes release therapeutic substances for chemotherapy in the acidic tumor tissue. As the level of ROS increases, the LnNPs shows responsively descending fluorescence intensity at 1550 nm excited by 980 nm (F1550, 980Ex), while the fluorescence of the LnNPs at 1060 nm excited by 808 nm (F1060, 808Ex) is stable. Due to the ratiometric F1550, 980Ex/F1060, 808Ex value exhibiting a linear relationship with ROS concentration, NIR-II imaging results of ROS change based on this ratio can be an important basis for determining tumor drug resistance. As the chemotherapy and resistance evaluation are explored continuously in situ, the ratiometric imaging identifies drug resistance successfully within 24 h, which can greatly improve the timeliness of accurate treatment.