Relationship between Hypoxic and Immune Pathways Activation in the Progression of Neuroinflammation: Role of HIF-1α and Th17 Cells

Neuroinflammation is a common event in degenerative diseases of the central and peripheral nervous system, triggered by alterations in the immune system or inflammatory cascade. The pathophysiology of these disorders is multifactorial, whereby the therapy available has low clinical efficacy. This re...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 24; no. 4; p. 3073
Main Authors:	Arias, Consuelo, Sepúlveda, Paulina, Castillo, Rodrigo L, Salazar, Luis A
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-02-2023 MDPI
Subjects:	Alzheimer's disease Analysis Angiogenesis Antigens Arthritis Autoimmune diseases B cells Cytokines Cytotoxicity Deregulation Development and progression Guillain-Barre syndrome Guillain-Barre Syndrome - pathology Health aspects Helper cells HIF-1α Homeostasis Humans Hypoxia Hypoxia - pathology Hypoxia-Inducible Factor 1, alpha Subunit Hypoxia-inducible factor 1a Immune system Inflammation Inflammatory diseases Kinases Lymphocytes Lymphocytes T Metabolism Multiple sclerosis Nervous system neuroinflammation Neuroinflammatory Diseases Pathogens Pathophysiology Peripheral nervous system Physiology Proteins Review Th17 Th17 Cells Therapeutic targets Transcription factors Tumor necrosis factor-TNF autoimmune diseases hypoxia HIF-1α neuroinflammation Th17
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Summary:	Neuroinflammation is a common event in degenerative diseases of the central and peripheral nervous system, triggered by alterations in the immune system or inflammatory cascade. The pathophysiology of these disorders is multifactorial, whereby the therapy available has low clinical efficacy. This review propounds the relationship between the deregulation of T helper cells and hypoxia, mainly Th17 and HIF-1α molecular pathways, events that are involved in the occurrence of the neuroinflammation. The clinical expression of neuroinflammation is included in prevalent pathologies such as multiple sclerosis, Guillain-Barré syndrome, and Alzheimer's disease, among others. In addition, therapeutic targets are analyzed in relation to the pathways that induced neuroinflammation.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms24043073