Pathological Relationship between Intracellular Superoxide Metabolism and p53 Signaling in Mice
Intracellular superoxide dismutases (SODs) maintain tissue homeostasis via superoxide metabolism. We previously reported that intracellular reactive oxygen species (ROS), including superoxide accumulation caused by cytoplasmic SOD (SOD1) or mitochondrial SOD (SOD2) insufficiency, induced p53 activat...
Saved in:
| Published in: | International journal of molecular sciences Vol. 22; no. 7; p. 3548 |
|---|---|
| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Switzerland
MDPI AG
29-03-2021
MDPI |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Intracellular superoxide dismutases (SODs) maintain tissue homeostasis via superoxide metabolism. We previously reported that intracellular reactive oxygen species (ROS), including superoxide accumulation caused by cytoplasmic SOD (SOD1) or mitochondrial SOD (SOD2) insufficiency, induced p53 activation in cells. SOD1 loss also induced several age-related pathological changes associated with increased oxidative molecules in mice. To evaluate the contribution of p53 activation for SOD1 knockout (KO) (
) mice, we generated SOD1 and p53 KO (double-knockout (DKO)) mice. DKO fibroblasts showed increased cell viability with decreased apoptosis compared with
fibroblasts. In vivo experiments revealed that p53 insufficiency was not a great contributor to aging-like tissue changes but accelerated tumorigenesis in
mice. Furthermore, p53 loss failed to improve dilated cardiomyopathy or the survival in heart-specific SOD2 conditional KO mice. These data indicated that p53 regulated ROS-mediated apoptotic cell death and tumorigenesis but not ROS-mediated tissue degeneration in SOD-deficient models. |
|---|---|
| AbstractList | Intracellular superoxide dismutases (SODs) maintain tissue homeostasis via superoxide metabolism. We previously reported that intracellular reactive oxygen species (ROS), including superoxide accumulation caused by cytoplasmic SOD (SOD1) or mitochondrial SOD (SOD2) insufficiency, induced p53 activation in cells. SOD1 loss also induced several age-related pathological changes associated with increased oxidative molecules in mice. To evaluate the contribution of p53 activation for SOD1 knockout (KO) (
Sod1
−
/
−
) mice, we generated SOD1 and p53 KO (double-knockout (DKO)) mice. DKO fibroblasts showed increased cell viability with decreased apoptosis compared with
Sod1
−
/
−
fibroblasts. In vivo experiments revealed that p53 insufficiency was not a great contributor to aging-like tissue changes but accelerated tumorigenesis in
Sod1
−
/
−
mice. Furthermore, p53 loss failed to improve dilated cardiomyopathy or the survival in heart-specific SOD2 conditional KO mice. These data indicated that p53 regulated ROS-mediated apoptotic cell death and tumorigenesis but not ROS-mediated tissue degeneration in SOD-deficient models. Intracellular superoxide dismutases (SODs) maintain tissue homeostasis via superoxide metabolism. We previously reported that intracellular reactive oxygen species (ROS), including superoxide accumulation caused by cytoplasmic SOD (SOD1) or mitochondrial SOD (SOD2) insufficiency, induced p53 activation in cells. SOD1 loss also induced several age-related pathological changes associated with increased oxidative molecules in mice. To evaluate the contribution of p53 activation for SOD1 knockout (KO) (Sod1−/−) mice, we generated SOD1 and p53 KO (double-knockout (DKO)) mice. DKO fibroblasts showed increased cell viability with decreased apoptosis compared with Sod1−/− fibroblasts. In vivo experiments revealed that p53 insufficiency was not a great contributor to aging-like tissue changes but accelerated tumorigenesis in Sod1−/− mice. Furthermore, p53 loss failed to improve dilated cardiomyopathy or the survival in heart-specific SOD2 conditional KO mice. These data indicated that p53 regulated ROS-mediated apoptotic cell death and tumorigenesis but not ROS-mediated tissue degeneration in SOD-deficient models. Intracellular superoxide dismutases (SODs) maintain tissue homeostasis via superoxide metabolism. We previously reported that intracellular reactive oxygen species (ROS), including superoxide accumulation caused by cytoplasmic SOD (SOD1) or mitochondrial SOD (SOD2) insufficiency, induced p53 activation in cells. SOD1 loss also induced several age-related pathological changes associated with increased oxidative molecules in mice. To evaluate the contribution of p53 activation for SOD1 knockout (KO) ( ) mice, we generated SOD1 and p53 KO (double-knockout (DKO)) mice. DKO fibroblasts showed increased cell viability with decreased apoptosis compared with fibroblasts. In vivo experiments revealed that p53 insufficiency was not a great contributor to aging-like tissue changes but accelerated tumorigenesis in mice. Furthermore, p53 loss failed to improve dilated cardiomyopathy or the survival in heart-specific SOD2 conditional KO mice. These data indicated that p53 regulated ROS-mediated apoptotic cell death and tumorigenesis but not ROS-mediated tissue degeneration in SOD-deficient models. |
| Author | Watanabe, Kenji Toda, Toshihiko Shibuya, Shuichi Ozawa, Yusuke Shimizu, Takahiko |
| AuthorAffiliation | 1 Aging Stress Response Research Project Team, National Center for Geriatrics and Gerontology, Obu 474-8511, Aichi, Japan; kng-wtnb@ncgg.go.jp (K.W.); s-shibuya@ncgg.go.jp (S.S.) 2 Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-8677, Chiba, Japan; ozawayusuke3@gmail.com (Y.O.); hik_toda@proteome.jp (T.T.) |
| AuthorAffiliation_xml | – name: 2 Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-8677, Chiba, Japan; ozawayusuke3@gmail.com (Y.O.); hik_toda@proteome.jp (T.T.) – name: 1 Aging Stress Response Research Project Team, National Center for Geriatrics and Gerontology, Obu 474-8511, Aichi, Japan; kng-wtnb@ncgg.go.jp (K.W.); s-shibuya@ncgg.go.jp (S.S.) |
| Author_xml | – sequence: 1 givenname: Kenji orcidid: 0000-0003-1707-1676 surname: Watanabe fullname: Watanabe, Kenji organization: Aging Stress Response Research Project Team, National Center for Geriatrics and Gerontology, Obu 474-8511, Aichi, Japan – sequence: 2 givenname: Shuichi surname: Shibuya fullname: Shibuya, Shuichi organization: Aging Stress Response Research Project Team, National Center for Geriatrics and Gerontology, Obu 474-8511, Aichi, Japan – sequence: 3 givenname: Yusuke surname: Ozawa fullname: Ozawa, Yusuke organization: Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-8677, Chiba, Japan – sequence: 4 givenname: Toshihiko orcidid: 0000-0003-2522-9699 surname: Toda fullname: Toda, Toshihiko organization: Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-8677, Chiba, Japan – sequence: 5 givenname: Takahiko orcidid: 0000-0002-3351-3342 surname: Shimizu fullname: Shimizu, Takahiko organization: Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba 260-8677, Chiba, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33805584$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVkcuLFDEQxoOsuA-9eZaAV0fTeXZfBFl8DOyiuHoO1Ul1T4ZMMibdPv57e511mT1VUfXxq4_6zslJygkJed6w10J07E3Y7irnzAgl20fkrJGcrxjT5uSoPyXntW4Z44Kr7gk5FaJlSrXyjNgvMG1yzGNwEOlXjDCFnOom7GmP0y_ERNdpKuAwxjlCoTfzHkv-HTzSa5ygzzHUHYXk6V4JehPGBDGkkYZEr4PDp-TxALHis7t6Qb5_eP_t8tPq6vPH9eW7q5VTUk6roRFm4BK9FrzT_eDd4loxrY3nRnEthHSD7w16aDs0slOOGd30Qg2tElKJC7I-cH2Grd2XsIPyx2YI9t8gl9FCmYKLaA3XSgOAcgol9NDLpuGtbpnuhUehF9bbA2s_9zv0Dm8fEB9AH25S2Ngx_7QtE6blzQJ4eQco-ceMdbLbPJflMdXyJSXTCd7wRfXqoHIl11pwuL_QMHsbrT2OdpG_OHZ1L_6fpfgLb9ehpg |
| CitedBy_id | crossref_primary_10_1134_S0026893322060188 |
| Cites_doi | 10.1074/jbc.M602118200 10.1371/journal.pone.0203944 10.1016/j.freeradbiomed.2010.02.011 10.1002/jbmr.1981 10.2353/ajpath.2008.070730 10.1038/srep09148 10.1038/nature13034 10.1080/09168451.2014.915728 10.1016/j.jid.2018.10.012 10.1016/j.redox.2018.11.014 10.1016/j.mad.2015.01.004 10.1155/2014/140165 10.2174/1381612811319150005 10.1095/biolreprod.111.092999 10.3390/ijms16022641 10.1155/2014/704291 10.1016/S0021-9258(19)84085-1 10.1161/CIRCRESAHA.109.214346 10.18632/oncotarget.25267 10.3390/ijms140610998 10.1016/j.ajpath.2012.01.019 10.1002/jbmr.489 10.1253/circj.CJ-09-0204 10.1089/ars.2012.4920 10.1182/blood-2017-07-746396 10.1016/0092-8674(91)90557-F 10.1161/JAHA.113.000779 10.1016/S0006-291X(02)00933-6 10.1038/onc.2016.32 10.3920/9789086867295_022 10.4081/ejh.2014.2383 10.1016/j.abb.2020.108701 10.1620/tjem.205.171 10.1210/jc.2002-021496 10.1038/ncomms3308 10.1073/pnas.94.6.2345 10.1038/srep11722 10.1111/j.1447-0594.2010.00604.x 10.1371/journal.pone.0109288 10.1038/s41598-019-57147-7 10.1002/jat.2854 10.1016/S0891-5849(98)00109-9 10.3389/fpls.2016.00842 10.1371/journal.pone.0234872 10.1038/sj.onc.1208207 10.1042/BJ20061386 10.1038/cdd.2013.52 10.1101/gad.10.19.2438 10.1074/jbc.M105395200 10.1073/pnas.0602131103 10.1155/2015/391075 10.1074/jbc.M111.279208 10.1155/2015/238914 10.1016/j.freeradbiomed.2020.01.023 10.1536/ihj.17-519 10.1016/j.freeradbiomed.2006.01.036 10.1038/ng1295-376 10.1007/s12011-010-8869-9 10.1038/cdd.2015.4 10.1038/s41419-017-0093-5 10.1371/journal.pone.0059167 10.1136/jclinpath-2018-205320 10.1038/nature05602 10.1101/gad.14.8.994 10.1007/s10495-018-1481-8 10.1021/mp300147v |
| ContentType | Journal Article |
| Copyright | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2021 by the authors. 2021 |
| Copyright_xml | – notice: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2021 by the authors. 2021 |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7X7 7XB 88E 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH K9. M0S M1P M2O MBDVC PIMPY PQEST PQQKQ PQUKI PRINS Q9U 5PM DOA |
| DOI | 10.3390/ijms22073548 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) Medical Database ProQuest research library Research Library (Corporate) Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic PubMed Central (Full Participant titles) Directory of Open Access Journals |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database Research Library Prep ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Research Library ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) |
| DatabaseTitleList | CrossRef Publicly Available Content Database MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: http://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1422-0067 |
| ExternalDocumentID | oai_doaj_org_article_72656aaa5c5e4abab411286806b3de36 10_3390_ijms22073548 33805584 |
| Genre | Journal Article |
| GroupedDBID | --- 29J 2WC 3V. 53G 5GY 5VS 7X7 88E 8FE 8FG 8FH 8FI 8FJ 8G5 A8Z AADQD AAFWJ AAHBH ABDBF ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ADBBV AEAQA AENEX AFKRA AFZYC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI CCPQU CGR CS3 CUY CVF D1I DIK DU5 DWQXO E3Z EBD EBS ECM EIF EJD ESTFP ESX F5P FRP FYUFA GNUQQ GROUPED_DOAJ GUQSH GX1 HCIFZ HH5 HMCUK HYE IAO ITC KB. KQ8 LK8 M1P M2O M48 M7P MODMG M~E NPM O5R O5S OK1 P2P PDBOC PIMPY PQQKQ PROAC PSQYO RIG RNS RPM TR2 TUS UKHRP ~8M AAYXX CITATION 7XB 8FK K9. MBDVC PQEST PQUKI PRINS Q9U 5PM AFPKN |
| ID | FETCH-LOGICAL-c544t-f137f24ed63296bfdc06750667d27526334cfdb7eda89e7495c0761b35f853453 |
| IEDL.DBID | RPM |
| ISSN | 1422-0067 1661-6596 |
| IngestDate | Tue Oct 22 15:14:53 EDT 2024 Tue Sep 17 21:24:52 EDT 2024 Thu Oct 10 19:51:31 EDT 2024 Fri Nov 22 03:30:06 EST 2024 Sat Nov 02 12:08:34 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Keywords | apoptosis aging superoxide superoxide dismutase (SOD) p53 |
| Language | English |
| License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c544t-f137f24ed63296bfdc06750667d27526334cfdb7eda89e7495c0761b35f853453 |
| ORCID | 0000-0003-1707-1676 0000-0003-2522-9699 0000-0002-3351-3342 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037821/ |
| PMID | 33805584 |
| PQID | 2548793212 |
| PQPubID | 2032341 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_72656aaa5c5e4abab411286806b3de36 pubmedcentral_primary_oai_pubmedcentral_nih_gov_8037821 proquest_journals_2548793212 crossref_primary_10_3390_ijms22073548 pubmed_primary_33805584 |
| PublicationCentury | 2000 |
| PublicationDate | 20210329 |
| PublicationDateYYYYMMDD | 2021-03-29 |
| PublicationDate_xml | – month: 3 year: 2021 text: 20210329 day: 29 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland – name: Basel |
| PublicationTitle | International journal of molecular sciences |
| PublicationTitleAlternate | Int J Mol Sci |
| PublicationYear | 2021 |
| Publisher | MDPI AG MDPI |
| Publisher_xml | – name: MDPI AG – name: MDPI |
| References | Sunagawa (ref_60) 2014; 2014 Chellappan (ref_56) 1991; 65 Imamura (ref_7) 2006; 103 ref_12 Sano (ref_29) 2007; 446 Montero (ref_41) 2013; 20 Mezzetti (ref_53) 1998; 25 Storr (ref_40) 2013; 18 ref_19 Elchuri (ref_14) 2005; 24 Tsukada (ref_35) 1993; 8 Watanabe (ref_1) 2014; 2014 Hayakawa (ref_61) 2012; 9 Czarny (ref_37) 2015; 16 Arcucci (ref_64) 2014; 58 Maggio (ref_4) 2003; 88 Hashizume (ref_8) 2008; 172 Lee (ref_39) 2019; 25 Ou (ref_36) 2018; 131 Bissinger (ref_43) 2018; 23 Kojima (ref_45) 2012; 180 ref_67 Noda (ref_46) 2012; 86 Cao (ref_5) 2018; 71 Simabuco (ref_38) 2018; 9 Nojiri (ref_10) 2011; 26 Iuchi (ref_9) 2007; 402 Formigari (ref_51) 2013; 33 Morita (ref_28) 2018; 59 Shimizu (ref_2) 2010; 10 Li (ref_21) 1995; 11 Shibuya (ref_18) 2014; 78 Watanabe (ref_20) 2013; 14 Koike (ref_27) 2015; 5 Watanabe (ref_16) 2015; 2015 Johnson (ref_57) 2016; 35 Marino (ref_66) 2000; 14 ref_32 Kawakami (ref_62) 2009; 73 Beltrami (ref_59) 2013; 19 Sun (ref_31) 2014; 3 Akdogan (ref_48) 2005; 205 Izuo (ref_25) 2015; 2015 Gu (ref_34) 2018; 9 Rouphael (ref_49) 2016; 7 Kuwahara (ref_24) 2010; 48 Fridovich (ref_3) 2001; 276 McCurrach (ref_42) 1997; 94 Hoshino (ref_33) 2013; 4 Morikawa (ref_11) 2013; 28 Uchiyama (ref_15) 2006; 281 Ikegami (ref_22) 2002; 296 Malavolta (ref_52) 2015; 151 Chen (ref_55) 1996; 10 Zenarruzabeitia (ref_58) 2015; 22 Tseng (ref_65) 2020; 10 Spencer (ref_47) 2014; 508 Guo (ref_63) 2020; 152 Kobayashi (ref_26) 2015; 5 Naito (ref_30) 2010; 106 Kim (ref_17) 2019; 139 Murakami (ref_44) 2011; 286 Nojiri (ref_23) 2006; 281 Sun (ref_50) 2011; 143 Muller (ref_13) 2006; 40 Eleutherio (ref_54) 2021; 697 ref_6 |
| References_xml | – volume: 281 start-page: 33789 year: 2006 ident: ref_23 article-title: Oxidative stress causes heart failure with impaired mitochondrial respiration publication-title: J. Biol. Chem. doi: 10.1074/jbc.M602118200 contributor: fullname: Nojiri – ident: ref_6 doi: 10.1371/journal.pone.0203944 – volume: 48 start-page: 1252 year: 2010 ident: ref_24 article-title: Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2010.02.011 contributor: fullname: Kuwahara – volume: 28 start-page: 2368 year: 2013 ident: ref_11 article-title: Cytoplasmic reactive oxygen species and SOD1 regulate bone mass during mechanical unloading publication-title: J. Bone Miner. Res. doi: 10.1002/jbmr.1981 contributor: fullname: Morikawa – volume: 172 start-page: 1325 year: 2008 ident: ref_8 article-title: Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2008.070730 contributor: fullname: Hashizume – volume: 5 start-page: 9148 year: 2015 ident: ref_26 article-title: Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis publication-title: Sci. Rep. doi: 10.1038/srep09148 contributor: fullname: Kobayashi – volume: 508 start-page: 269 year: 2014 ident: ref_47 article-title: Direct measurement of local oxygen concentration in the bone marrow of live animals publication-title: Nature doi: 10.1038/nature13034 contributor: fullname: Spencer – volume: 78 start-page: 1212 year: 2014 ident: ref_18 article-title: Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice publication-title: Biosci. Biotechnol. Biochem. doi: 10.1080/09168451.2014.915728 contributor: fullname: Shibuya – volume: 139 start-page: 648 year: 2019 ident: ref_17 article-title: Syringaresinol Reverses Age-Related Skin Atrophy by Suppressing FoxO3a-Mediated Matrix Metalloproteinase-2 Activation in Copper/Zinc Superoxide Dismutase-Deficient Mice publication-title: J. Investig. Dermatol. doi: 10.1016/j.jid.2018.10.012 contributor: fullname: Kim – volume: 25 start-page: 101056 year: 2019 ident: ref_39 article-title: Redox regulation of cell state and fate publication-title: Redox Biol. doi: 10.1016/j.redox.2018.11.014 contributor: fullname: Lee – volume: 151 start-page: 93 year: 2015 ident: ref_52 article-title: Serum copper to zinc ratio: Relationship with aging and health status publication-title: Mech. Ageing Dev. doi: 10.1016/j.mad.2015.01.004 contributor: fullname: Malavolta – volume: 2014 start-page: 140165 year: 2014 ident: ref_1 article-title: Superoxide dismutase 1 loss disturbs intracellular redox signaling, resulting in global age-related pathological changes publication-title: Biomed. Res. Int. doi: 10.1155/2014/140165 contributor: fullname: Watanabe – volume: 19 start-page: 2708 year: 2013 ident: ref_59 article-title: The p53-p66Shc apoptotic pathway is dispensable for tumor suppression whereas the p66Shc-generated oxidative stress initiates tumorigenesis publication-title: Curr. Pharm. Des. doi: 10.2174/1381612811319150005 contributor: fullname: Beltrami – volume: 86 start-page: 1 year: 2012 ident: ref_46 article-title: Copper/zinc superoxide dismutase insufficiency impairs progesterone secretion and fertility in female mice publication-title: Biol. Reprod. doi: 10.1095/biolreprod.111.092999 contributor: fullname: Noda – volume: 16 start-page: 2641 year: 2015 ident: ref_37 article-title: Autophagy in DNA damage response publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms16022641 contributor: fullname: Czarny – volume: 2014 start-page: 704291 year: 2014 ident: ref_60 article-title: Cardiac electrophysiological alterations in heart/muscle-specific manganese-superoxide dismutase-deficient mice: Prevention by a dietary antioxidant polyphenol publication-title: Biomed. Res. Int. doi: 10.1155/2014/704291 contributor: fullname: Sunagawa – volume: 281 start-page: 31713 year: 2006 ident: ref_15 article-title: CuZn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in mice publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)84085-1 contributor: fullname: Uchiyama – volume: 106 start-page: 1692 year: 2010 ident: ref_30 article-title: Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.109.214346 contributor: fullname: Naito – volume: 9 start-page: 23780 year: 2018 ident: ref_38 article-title: p53 and metabolism: From mechanism to therapeutics publication-title: Oncotarget doi: 10.18632/oncotarget.25267 contributor: fullname: Simabuco – volume: 14 start-page: 10998 year: 2013 ident: ref_20 article-title: Sod1 loss induces intrinsic superoxide accumulation leading to p53-mediated growth arrest and apoptosis publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms140610998 contributor: fullname: Watanabe – volume: 180 start-page: 1879 year: 2012 ident: ref_45 article-title: Age-related dysfunction of the lacrimal gland and oxidative stress: Evidence from the Cu,Zn-superoxide dismutase-1 (Sod1) knockout mice publication-title: Am. J. Pathol. doi: 10.1016/j.ajpath.2012.01.019 contributor: fullname: Kojima – volume: 26 start-page: 2682 year: 2011 ident: ref_10 article-title: Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking publication-title: J. Bone Miner. Res. doi: 10.1002/jbmr.489 contributor: fullname: Nojiri – volume: 73 start-page: 2125 year: 2009 ident: ref_62 article-title: Antioxidant, EUK-8, prevents murine dilated cardiomyopathy publication-title: Circ. J. doi: 10.1253/circj.CJ-09-0204 contributor: fullname: Kawakami – volume: 18 start-page: 2399 year: 2013 ident: ref_40 article-title: Redox environment, free radical, and oxidative DNA damage publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2012.4920 contributor: fullname: Storr – volume: 131 start-page: 488 year: 2018 ident: ref_36 article-title: DNA damage responses and p53 in the aging process publication-title: Blood doi: 10.1182/blood-2017-07-746396 contributor: fullname: Ou – volume: 65 start-page: 1053 year: 1991 ident: ref_56 article-title: The E2F transcription factor is a cellular target for the RB protein publication-title: Cell doi: 10.1016/0092-8674(91)90557-F contributor: fullname: Chellappan – volume: 3 start-page: e000779 year: 2014 ident: ref_31 article-title: Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice publication-title: J. Am. Heart Assoc. doi: 10.1161/JAHA.113.000779 contributor: fullname: Sun – volume: 296 start-page: 729 year: 2002 ident: ref_22 article-title: Model mice for tissue-specific deletion of the manganese superoxide dismutase (MnSOD) gene publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/S0006-291X(02)00933-6 contributor: fullname: Ikegami – volume: 35 start-page: 4829 year: 2016 ident: ref_57 article-title: Targeting the RB-E2F pathway in breast cancer publication-title: Oncogene doi: 10.1038/onc.2016.32 contributor: fullname: Johnson – volume: 8 start-page: 3313 year: 1993 ident: ref_35 article-title: Enhanced proliferative potential in culture of cells from p53-deficient mice publication-title: Oncogene contributor: fullname: Tsukada – ident: ref_12 doi: 10.3920/9789086867295_022 – volume: 58 start-page: 2383 year: 2014 ident: ref_64 article-title: Analysis of extracellular superoxide dismutase and Akt in ascending aortic aneurysm with tricuspid or bicuspid aortic valve publication-title: Eur. J. Histochem. doi: 10.4081/ejh.2014.2383 contributor: fullname: Arcucci – volume: 697 start-page: 108701 year: 2021 ident: ref_54 article-title: SOD1, more than just an antioxidant publication-title: Arch. Biochem. Biophys. doi: 10.1016/j.abb.2020.108701 contributor: fullname: Eleutherio – volume: 205 start-page: 171 year: 2005 ident: ref_48 article-title: Granule cell apoptosis induced by overdose copper and ethanol is counterbalanced by co-induced cellular proliferation in rat dentate gyrus publication-title: Tohoku J. Exp. Med. doi: 10.1620/tjem.205.171 contributor: fullname: Akdogan – volume: 88 start-page: 1523 year: 2003 ident: ref_4 article-title: Marked decrease in plasma antioxidants in aged osteoporotic women: Results of a cross-sectional study publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2002-021496 contributor: fullname: Maggio – volume: 4 start-page: 2308 year: 2013 ident: ref_33 article-title: Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart publication-title: Nat. Commun. doi: 10.1038/ncomms3308 contributor: fullname: Hoshino – volume: 94 start-page: 2345 year: 1997 ident: ref_42 article-title: bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.94.6.2345 contributor: fullname: McCurrach – volume: 5 start-page: 11722 year: 2015 ident: ref_27 article-title: Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration publication-title: Sci. Rep. doi: 10.1038/srep11722 contributor: fullname: Koike – volume: 10 start-page: S70 year: 2010 ident: ref_2 article-title: Model mice for tissue-specific deletion of the manganese superoxide dismutase gene publication-title: Geriat. Gerontol. Int. doi: 10.1111/j.1447-0594.2010.00604.x contributor: fullname: Shimizu – ident: ref_19 doi: 10.1371/journal.pone.0109288 – volume: 10 start-page: 280 year: 2020 ident: ref_65 article-title: Extracellular Superoxide Dismutase Regulates Early Vascular Hyaluronan Remodeling in Hypoxic Pulmonary Hypertension publication-title: Sci. Rep. doi: 10.1038/s41598-019-57147-7 contributor: fullname: Tseng – volume: 33 start-page: 527 year: 2013 ident: ref_51 article-title: The effect of zinc and the role of p53 in copper-induced cellular stress responses publication-title: J. Appl. Toxicol. doi: 10.1002/jat.2854 contributor: fullname: Formigari – volume: 25 start-page: 676 year: 1998 ident: ref_53 article-title: Copper/zinc ratio and systemic oxidant load: Effect of aging and aging-related degenerative diseases publication-title: Free Radic. Biol. Med. doi: 10.1016/S0891-5849(98)00109-9 contributor: fullname: Mezzetti – volume: 7 start-page: 842 year: 2016 ident: ref_49 article-title: Zinc Excess Triggered Polyamines Accumulation in Lettuce Root Metabolome, As Compared to Osmotic Stress under High Salinity publication-title: Front. Plant. Sci. doi: 10.3389/fpls.2016.00842 contributor: fullname: Rouphael – ident: ref_32 doi: 10.1371/journal.pone.0234872 – volume: 24 start-page: 367 year: 2005 ident: ref_14 article-title: CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life publication-title: Oncogene doi: 10.1038/sj.onc.1208207 contributor: fullname: Elchuri – volume: 402 start-page: 219 year: 2007 ident: ref_9 article-title: Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production publication-title: Biochem. J. doi: 10.1042/BJ20061386 contributor: fullname: Iuchi – volume: 20 start-page: 1465 year: 2013 ident: ref_41 article-title: p53 regulates a non-apoptotic death induced by ROS publication-title: Cell Death Differ. doi: 10.1038/cdd.2013.52 contributor: fullname: Montero – volume: 10 start-page: 2438 year: 1996 ident: ref_55 article-title: p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells publication-title: Genes Dev. doi: 10.1101/gad.10.19.2438 contributor: fullname: Chen – volume: 276 start-page: 38388 year: 2001 ident: ref_3 article-title: Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria publication-title: J. Biol. Chem. doi: 10.1074/jbc.M105395200 contributor: fullname: Fridovich – volume: 103 start-page: 11282 year: 2006 ident: ref_7 article-title: Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: A model of age-related macular degeneration publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0602131103 contributor: fullname: Imamura – volume: 2015 start-page: 391075 year: 2015 ident: ref_16 article-title: Resveratrol Derivative-Rich Melinjo Seed Extract Attenuates Skin Atrophy in Sod1-Deficient Mice publication-title: Oxid. Med. Cell Longev. doi: 10.1155/2015/391075 contributor: fullname: Watanabe – volume: 286 start-page: 44557 year: 2011 ident: ref_44 article-title: SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.279208 contributor: fullname: Murakami – volume: 2015 start-page: 238914 year: 2015 ident: ref_25 article-title: Brain-Specific Superoxide Dismutase 2 Deficiency Causes Perinatal Death with Spongiform Encephalopathy in Mice publication-title: Oxid. Med. Cell Longev. doi: 10.1155/2015/238914 contributor: fullname: Izuo – volume: 152 start-page: 787 year: 2020 ident: ref_63 article-title: Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3 publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2020.01.023 contributor: fullname: Guo – volume: 59 start-page: 6 year: 2018 ident: ref_28 article-title: Heart Failure as an Aging-Related Phenotype publication-title: Int. Heart J. doi: 10.1536/ihj.17-519 contributor: fullname: Morita – volume: 40 start-page: 1993 year: 2006 ident: ref_13 article-title: Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2006.01.036 contributor: fullname: Muller – volume: 11 start-page: 376 year: 1995 ident: ref_21 article-title: Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase publication-title: Nat. Genet. doi: 10.1038/ng1295-376 contributor: fullname: Li – volume: 143 start-page: 394 year: 2011 ident: ref_50 article-title: Effects of zinc supplementation and deficiency on bone metabolism and related gene expression in rat publication-title: Biol. Trace Elem. Res. doi: 10.1007/s12011-010-8869-9 contributor: fullname: Sun – volume: 22 start-page: 1577 year: 2015 ident: ref_58 article-title: E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution publication-title: Cell Death Differ. doi: 10.1038/cdd.2015.4 contributor: fullname: Zenarruzabeitia – volume: 9 start-page: 82 year: 2018 ident: ref_34 article-title: Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis publication-title: Cell Death Dis. doi: 10.1038/s41419-017-0093-5 contributor: fullname: Gu – ident: ref_67 doi: 10.1371/journal.pone.0059167 – volume: 71 start-page: 1090 year: 2018 ident: ref_5 article-title: Reduced expression of SIRT1 and SOD-1 and the correlation between these levels in various regions of the brains of patients with Alzheimer’s disease publication-title: J. Clin. Pathol. doi: 10.1136/jclinpath-2018-205320 contributor: fullname: Cao – volume: 446 start-page: 444 year: 2007 ident: ref_29 article-title: p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload publication-title: Nature doi: 10.1038/nature05602 contributor: fullname: Sano – volume: 14 start-page: 994 year: 2000 ident: ref_66 article-title: Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum publication-title: Genes Dev. doi: 10.1101/gad.14.8.994 contributor: fullname: Marino – volume: 23 start-page: 641 year: 2018 ident: ref_43 article-title: Genetic deficiency of the tumor suppressor protein p53 influences erythrocyte survival publication-title: Apoptosis doi: 10.1007/s10495-018-1481-8 contributor: fullname: Bissinger – volume: 9 start-page: 2956 year: 2012 ident: ref_61 article-title: Pharmaceutical effect of manganese porphyrins on manganese superoxide dismutase deficient mice publication-title: Mol. Pharm. doi: 10.1021/mp300147v contributor: fullname: Hayakawa |
| SSID | ssj0023259 |
| Score | 2.363608 |
| Snippet | Intracellular superoxide dismutases (SODs) maintain tissue homeostasis via superoxide metabolism. We previously reported that intracellular reactive oxygen... |
| SourceID | doaj pubmedcentral proquest crossref pubmed |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | 3548 |
| SubjectTerms | Age Aging Alzheimer's disease Animals Antioxidants Apoptosis Apoptosis - genetics Atrophy Cardiomyocytes Cardiomyopathy Cell activation Cell cycle Cell death Cell growth Cell viability Degeneration Dilated cardiomyopathy DNA repair Female Fibroblasts Fibroblasts - metabolism Heart - physiopathology Heart failure Homeostasis In vitro fertilization Intracellular Intracellular signalling Male Mice Mice, Knockout Mice, Transgenic Mitochondria Neoplasms - genetics p53 p53 Protein Phenotype Rodents Signal Transduction - genetics Skin superoxide Superoxide dismutase superoxide dismutase (SOD) Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase-1 - genetics Superoxide Dismutase-1 - metabolism Superoxides - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumorigenesis |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Pa9RAFH7UgtCLWLU1WmUOegzNzu892l_UQ0XYCt7CJPOmjdi4uLug_73vJdmwWwpeek3CzPDeZN73JR_fA_iQYkDvFeapQJXrEEweYtB55al4IZFsV_Mf3cuZ-_Ldn52zTc7Y6os1Yb09cB-4YycJcQQaozaoQxUqTQjBW1_YSkVUvdl2YddkaqBaSnZt0iZUfXJrpraXvCua-7j5cbeQkna24Z4_G8Wo8-x_CGje10tuFKCL5_BsQI7iU7_ifdjB9gU87XtJ_n0J5dewHE8yMWrcbpu5GLRY4jOPy1_qWXoqZiv2CP_TRBRXuKS98LNZ3InQRjE3SsyaG4bo7Y1oWnFFp8kr-HZxfn16mQ_dE_LaaL3M00S5JDVGq-TUVinWTA5Y0xqlM9IqpevE5sox-Ck6Iko1f9OolElUwrVRB7Db_mrxNQiP01pbRCej0ZgwSKWKGFLUxmFVpww-rsNYznuTjJLIBYe73Ax3Bicc4_EZtrbuLlDCyyHh5f8SnsHROkPl8L4tSsnEi6DoRGZw2CdrnIVIeGEIZ2XgttK4tYztO21z2zlt-0IRgpq8eYx1v4U9yXqYgnvnHcHu8vcK38GTRVy97_buP3JA9IA priority: 102 providerName: Directory of Open Access Journals |
| Title | Pathological Relationship between Intracellular Superoxide Metabolism and p53 Signaling in Mice |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/33805584 https://www.proquest.com/docview/2548793212 https://pubmed.ncbi.nlm.nih.gov/PMC8037821 https://doaj.org/article/72656aaa5c5e4abab411286806b3de36 |
| Volume | 22 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9swDCaWAht6Kfaeuy7QYTu6cfSwlGPXtWgxZCiQDdjNkCUq9dC4QZMA7b8v5UfQDDvt6pcEkha_T_5MAnwO3qIxAtOQoUiltSq13sq0NJS8kEi2dvGL7sVM__htvp3FMjmq_xemEe27sjqubxbHdXXdaCuXCzfqdWKjq-mpyQQltvFoAAPChj1F71iWIEDfKtwFDTWq_ixWnFMgEzTfhxfEyDKljNxJQ021_n9BzL-Vkk9Sz_lLOOgwIztp5_YKnmH9Gp63XSQf3kBxZdfbNYxt1W3X1ZJ1Kix2GZ8b9-ij6JTNNrE6-H3lkU1xTVFwU60WzNaeLZVgs2oewXk9Z1XNprSOvIVf52c_Ty_Srm9C6pSU6zSMhQ5cos8Fn-Rl8C7Sgqhm9VwrngshXYhllb01E9REkVzczSiFCpS8pRLvYK--rfEDMIMTJ3NEzb2SGNByITJvg5dKY-lCAl96MxbLtjxGQbQiWr54avkEvkYbb6-JRa2bA7d386JzbaE5gUtL4eIUSlvaUhIYNLnJ8lJ4FHkCR72Hiu5NWxU8Ui4CoWOewPvWWdtRemcnoHfcuDON3TMUck2N7S7EDv_7zo-wz6P8JYut8o5gb323wU8wWPnNkJD75fdhw_6HTew-Asok9Qg |
| link.rule.ids | 230,315,729,782,786,866,887,2106,27933,27934,53800,53802 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFD5iQ8BeuF8CA_wAj1lTXxL3EcamTqzTpA6JN8uxj7ugNavWVoJ_z3Eu1Yp42mucyFa-Y5_vc74cA3wK3qLWAtOQoUiltSq13sq01JS8kER24eIX3fG0OPupvx3FMjmq_xemMe27sjqor-YHdXXZeCsXczfofWKD88mhzgQltuFgB-7TfM2yXqR3OksQpW897oI6G1S_5kvOKZSJnO_BQ9JkmVJabiWipl7__0jmv17JW8nn-Mkdh_0UHndsk31pm5_BPayfw4P2_Mk_L8Cc29Vm9WMbX9xltWCdf4udxPHE3f1oV2XTdawr_rvyyCa4ovi5qpZzZmvPFkqwaTWLtL6esapmE1qBXsKP46OLw3HanbiQOiXlKg1DUQQu0eeCj_IyeBcFRfTBel4ongshXYgFmb3VIyxIXLm4D1IKFSjtSyVewW59XeMbYBpHTuaIBfdKYkDLhci8DV6qAksXEvjcv36zaAtrGBIkETFzG7EEvkZsNvfEctjNheubmenerik40VJLgeYUSlvaUhKN1LnO8lJ4FHkC-z2yppujS8OjWCP6OuQJvG5B3vTSB0kCxRb8W8PYbiHUm-rcHcpv7_zkR3g0vpicmtOTs-_vYI9HE00WD9zbh93VzRrfw87Srz80Mf8XOAcIrg |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7RIqpeeJcGCvgAxzRZPxLvEdquWsFWKy1I3CzHj21QN426u1L594zzUhdxgmsespVv7Pk-59MMwAdvtZOSudinjsVcaxFrq3lcSExeDkV2bsIf3fN5fvlDnp6FMjlDq6_GtG-K8ri6Xh5X5VXjrayXJul9YslseiJTholtlNTWJzvwENdsSnuh3mkthrS-9bkzHDApfy5XlGI4I0Hfhz3UZakQkm8lo6Zm_9-I5p9-yXsJaPLkP6b-FB53rJN8ah95Bg9c9RwetX0of70ANdPrYRckgz_uqqxJ5-MiF2FO4ZQ_2FbJfBPqi9-V1pGpW2McXZerJdGVJbVgZF4uAr2vFqSsyBR3opfwfXL27eQ87jovxEZwvo79iOWecmczRsdZ4a0JwiL4YS3NBc0Y48aHwsxWy7HLUWSZcB5SMOEx_XPBDmC3uqncIRDpxoZnzuXUCu6805Sx1GpvuchdYXwEH3sIVN0W2FAoTAJq6j5qEXwO-AzPhLLYzYWb24XqvrDKKdJTjQFnhOO60AVHOikzmWYFs45lERz16Kpura4UDaINaeyIRvCqBXoYpQ-UCPKtENiaxvYdRL6p0t0h_fqf33wPe7PTifp6cfnlDezT4KVJQ9-9I9hd327cW9hZ2c27Jux_A4GRCy4 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pathological+Relationship+between+Intracellular+Superoxide+Metabolism+and+p53+Signaling+in+Mice&rft.jtitle=International+journal+of+molecular+sciences&rft.au=Watanabe%2C+Kenji&rft.au=Shibuya%2C+Shuichi&rft.au=Ozawa%2C+Yusuke&rft.au=Toda%2C+Toshihiko&rft.date=2021-03-29&rft.pub=MDPI+AG&rft.issn=1661-6596&rft.eissn=1422-0067&rft.volume=22&rft.issue=7&rft.spage=3548&rft_id=info:doi/10.3390%2Fijms22073548&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-0067&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-0067&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-0067&client=summon |