Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes

Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their de...

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Bibliographic Details
Published in:International journal of molecular sciences Vol. 18; no. 8; p. 1683
Main Authors: Ni, Shuaijian, Yao, Houzong, Wang, Lili, Lu, Jun, Jiang, Feng, Lu, Aiping, Zhang, Ge
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 02-08-2017
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Summary:Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms18081683