Food (Matrix) Effects on Bioaccessibility and Intestinal Permeability of Major Olive Antioxidants

• Published in: Foods Vol. 9; no. 12; p. 1831
• Main Authors: Vitali Čepo, Dubravka, Radić, Kristina, Turčić, Petra, Anić, Dora, Komar, Barbara, Šalov, Mirela
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09-12-2020; MDPI
• Subjects: Antioxidants; Bile; Bioavailability; Biological activity; Caco-2 monolayer; Casein; Dietary fiber; Dietary supplements; Digestibility; Disease; Food; Food matrix; Food science; Functional foods & nutraceuticals; Health promotion; hydroxytyrosol; in vitro digestion; In vitro methods and tests; Intestine; Investigations; Membrane permeability; Monolayers; Nutrients; Oils & fats; Olive oil; olive pomace; Permeability; Phenolic compounds; Phenols; Physiology; polyphenol-food interaction; Polyphenols; Sodium; Tyrosol; Vegetable oils; United States > US; Germany; Croatia; Caco-2 monolayer; polyphenol-food interaction; tyrosol; olive pomace; hydroxytyrosol; in vitro digestion
• ISSN: 2304-8158; 2304-8158
• DOI: 10.3390/foods9121831

olive pomace extract (OPE) is a rich source of health promoting polyphenols (hydroxytyrosol (HTS) and tyrosol (TS)) and can be used as a nutraceutical ingredient of dietary supplements and functional foods. Its adequate bioavailability is a prerequisite for excreting biological activity and can be significantly and specifically affected by different food matrices.
in order to investigate food effects on polyphenol bioaccessibility, OPE was co-digested with different foods according to internationally harmonized in vitro digestibility method. Impact of particular nutrients on HTS and TS permeability was assessed on Caco-2 cell monolayer.
HTS and TS bioaccessibility and transepithelial permeability can be significantly affected by foods (nutrients), especially by casein and certain types of dietary fiber. Those effects are polyphenol-and nutrient-specific and are achieved either through complexation in gastrointestinal lumen and/or through direct effects of nutrients on intestinal monolayer.
obtained results emphasize the significance and complexity of polyphenol interactions within the food matrix and the necessity of individual investigational approaches with respect to particular food/nutrient and interacting phenolic compounds.