Role of ferritin and oxidative stress index in gestational diabetes mellitus

• Published in: Journal of diabetes and metabolic disorders Vol. 20; no. 2; pp. 1615 - 1619
• Main Authors: Gautam, Surabhi, Alam, Feroz, Moin, Shagufta, Noor, Nasreen, Arif, S. H.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01-12-2021; BioMed Central Ltd
• Subjects: Blood sugar; Diabetes; Diabetes in pregnancy; Endocrinology; Ethylenediaminetetraacetic acid; Ferritin; Glycosylated hemoglobin; Health aspects; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Metabolic Diseases; Oxidative stress; Pregnant women; Research Article; Type 2 diabetes; Women; India; Gestational Diabetes Mellitus; Fenton reaction; Ferroptosis; Oxidative Stress Index; Ferritin
• ISSN: 2251-6581; 2251-6581
• DOI: 10.1007/s40200-021-00911-2

Objectives
To investigate the role of serum ferritin and oxidative stress in the development of GDM and to assess their relationship with the ensuing hyperglycemia.
Methods
A case–control study was carried on 90 non-anemic pregnant women of 20–40 years with a gestation of 24–28 weeks. Study group (n = 65) was identified according to the Diabetes in Pregnancy Study Group India (DIPSI) criteria (2-h plasma glucose ≥ 140 mg/dl) and controls (n = 25) having 2-h plasma glucose < 120 mg/dl. DIPSI 2-h plasma glucose, HbA1c and serum ferritin were measured and oxidative stress index (OSI) was calculated. Statistical tests were performed using SPSS version 25.0.
Results
Pre-pregnancy BMI showed a significant difference between control and study group. DIPSI 2 h blood glucose, HbA1c, serum ferritin and OSI were significantly higher in study group compared to control group. Both 2 h blood glucose and HbA1c were positively correlated with serum ferritin and OSI, serum ferritin and OSI were also positively correlated with each other.
Conclusion
Higher pre-pregnancy BMI elevates serum ferritin, which in turn increases the OSI. Both ferritin and oxidative stress raises 2 h blood glucose and HbA1c in GDM patients possibly by causing in-vivo pancreatic β –cell injury and death (ferroptosis). Serum ferritin and OSI could become newer personalized theranostic and monitoring targets in overweight/obese pregnant females especially GDM patients.