Phase waves and trigger waves: emergent properties of oscillating and excitable networks in the gut

• Published in: The Journal of physiology Vol. 596; no. 20; pp. 4819 - 4829
• Main Authors: Parsons, Sean P., Huizinga, Jan D.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 15-10-2018; John Wiley and Sons Inc
• Subjects: Contractility; Digestive system; Gastrointestinal Motility; Gastrointestinal tract; ICC; Interstitial cells of Cajal; Nonlinear systems; non‐linear dynamics; pacemaker networks; phase waves; Small intestine; Topical Review; trigger waves; pacemaker networks; Gastrointestinal Motility; phase waves; trigger waves; ICC; non-linear dynamics; Interstitial cells of Cajal
• ISSN: 0022-3751; 1469-7793
• DOI: 10.1113/JP273425

The gut is enmeshed by a number of cellular networks, but there is only a limited understanding of how these networks generate the complex patterns of activity that drive gut contractile functions. Here we review two fundamental types of cell behaviour, excitable and oscillating, and the patterns that networks of such cells generate, trigger waves and phase waves, respectively. We use both the language of biophysics and the theory of nonlinear dynamics to define these behaviours and understand how they generate patterns. Based on this we look for evidence of trigger and phase waves in the gut, including some of our recent work on the small intestine.
The membrane potential of an excitable cell depolarises in response to a depolarising trigger. In a network of excitable cells, coupled electrically by gap junctions, a wave of electrical excitation can thus spread like falling dominoes. This is a trigger wave. In a network of cells whose membrane potentials oscillate autonomously, gap junction coupling causes synchronisation with a lag, giving the appearance of a propagating wave. This is a phase wave. The same phenomenon can be seen in a variety of coupled oscillator systems, such as fireflies, electrical circuits, fluid vortices and metronomes.