Degree of Chemical Functionalization of Carbon Nanotubes Determines Tissue Distribution and Excretion Profile

Getting rid of the tubes: An assessment of the retention of functionalized multi‐walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy (see scheme). Increasing the degree of functionalization on MWNTs enha...

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Published in:	Angewandte Chemie International Edition Vol. 51; no. 26; pp. 6389 - 6393
Main Authors:	Al-Jamal, Khuloud T., Nunes, Antonio, Methven, Laura, Ali-Boucetta, Hanene, Li, Shouping, Toma, Francesca M., Herrero, M. Antonia, Al-Jamal, Wafa' T., ten Eikelder, Huub M. M., Foster, Julie, Mather, Stephen, Prato, Maurizio, Bianco, Alberto, Kostarelos, Kostas
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 25-06-2012 WILEY‐VCH Verlag Wiley Subscription Services, Inc Wiley-VCH Verlag
Edition:	International ed. in English
Subjects:	Amines - chemistry Amines - pharmacokinetics Animals Assessments biodistribution Carbon nanotubes Chemical Sciences Computation Excretion functionalization Medicinal Chemistry Mice Microscopy, Electron, Transmission Models, Molecular Molecular Structure Multi wall carbon nanotubes nanotubes Nanotubes, Carbon - chemistry Nanotubes, Carbon - ultrastructure Organ Specificity Organs pharmacokinetics Photon emission Tomography toxicology Tubes
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Summary:	Getting rid of the tubes: An assessment of the retention of functionalized multi‐walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy (see scheme). Increasing the degree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted reticuloendethelial system accumulation.
Bibliography:	European Commission FP7 ANTICARB - No. HEALTH-2007-201587 Italian Ministry of Education MUR - No. 20085M27SS; No. RBAP11ETKA Project for International Scientific Cooperation istex:145714D58CFBD258E17228DCEAD658FF7879E3FA Agence Nationale de la Recherche - No. ANR-05-JCJC-0031-01 PICS EPSRC - No. EP/G061998/1 INSTM Engineering and Physical Sciences Research Council ark:/67375/WNG-2NXG6D71-W CNRS CARBONANOBRIDGE - No. ERC-2008-AdG-227135 ArticleID:ANIE201201991 This work was partially supported by the Engineering and Physical Sciences Research Council (EPSRC) Grand Challenge grant (EP/G061998/1) and the European Commission FP7 ANTICARB (HEALTH-2007-201587), and CARBONANOBRIDGE (ERC-2008-AdG-227135) programs. M.P. acknowledges the University of Trieste, INSTM, Italian Ministry of Education MUR (Cofin Prot. 20085M27SS and Firb RBAP11ETKA), Regione Friuli Venezia-Giulia, and A.B. the CNRS and the Agence Nationale de la Recherche (grant ANR-05-JCJC-0031-01). Also, A.B. acknowledges the PICS (Project for International Scientific Cooperation) CNRS financial support. These authors contributed equally to this work. This work was partially supported by the Engineering and Physical Sciences Research Council (EPSRC) Grand Challenge grant (EP/G061998/1) and the European Commission FP7 ANTICARB (HEALTH‐2007‐201587), and CARBONANOBRIDGE (ERC‐2008‐AdG‐227135) programs. M.P. acknowledges the University of Trieste, INSTM, Italian Ministry of Education MUR (Cofin Prot. 20085M27SS and Firb RBAP11ETKA), Regione Friuli Venezia‐Giulia, and A.B. the CNRS and the Agence Nationale de la Recherche (grant ANR‐05‐JCJC‐0031‐01). Also, A.B. acknowledges the PICS (Project for International Scientific Cooperation) CNRS financial support. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201201991