Association of ACE Gene I/D polymorphism with migraine in Kashmiri population

• Published in: Annals of the Indian Academy of Neurology Vol. 19; no. 1; pp. 89 - 93
• Main Authors: Wani, Irfan Yousuf, Sheikh, Saleem, Shah, Zafar Amin, Pandith, Arshid A, Wani, Mushtaq, Asimi, Ravouf, Wani, Maqbool, Sheikh, Shahnawaz, Mehraj, Iqra
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01-01-2016; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: ACE gene; Age; Alzheimer's disease; Analysis; Deoxyribonucleic acid; DNA; Ethnicity; Family medical history; gene polymorphism; Genes; Genetic aspects; Genetic polymorphisms; Genetic testing; Genotype & phenotype; Headaches; Hypertension; Migraine; Neurology; Original; Polymorphism; Population; Studies; India; Kashmir; gene polymorphism; ACE gene; migraine
• ISSN: 0972-2327; 1998-3549
• DOI: 10.4103/0972-2327.167698

Migraine is a complex, recurrent headache disorder that is one of the most common complaints in neurology practice. The role of various genes in its pathogenesis is being studied. We did this study to see whether an association exists between ACE gene I/D polymorphism and migraine in our region.
The study included 100 patients diagnosed with migraine and 121 healthy controls. The study subject were age and gender matched. The analysis was based on Polymerase Chain Reaction (PCR) and included following steps: DNA extraction from blood, PCR and Restriction Fragment Length Polymorphism (RFLP).
Out of 100 cases, 69 were females and 31 were males. Fifty-seven were having migraine without aura and 43 had migraine with aura. 45 of the cases had II polymorphism, 40 had ID polymorphism and 15 had DD polymorphism in ACE gene.
We were not able to find a statistically significant association between ACE gene I/D polymorphism with migraine. The reason for difference in results between our study and other studies could be because of different ethnicity in study populations. So a continuous research is needed in this regard in order to find the genes and different polymorphism that increase the susceptibility of Kashmiri population to migraine.